Biophysical Manipulation of Functional Amyloids

Project ID: 525

Cube proposed by: Matthew Chapman

Unit: LSA: Natural Sciences

Cycle: MCubed 1.0

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About this project: 
This collaboration will foster an understanding of how proteins adopt very ordered aggregates called amyloid. Amyloid formation has a long-standing link to human neurodegenerative diseases like Alzheimer's and Parkinson's. However, there is a growing amyloids can also be formed by cellular proteins and that these stable fibers can contribute to cellular fitness. We will explore how certain 'functional amyloids' adopt stable polymers without causing cytotoxicity.