Design, synthesis, and imaging of novel bone adhesives

Project ID: 560

Cube proposed by: Emmanuelle Marquis

Unit: Engineering

Cycle: MCubed 1.0

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About this project: 
With the advent of self etch adhesives used to bond composite materials to dentin in Dentistry, the “ideal” bone adhesive may be achievable. We therefore propose to develop a biocompatible, non-toxic self etch adhesive filled with bioactive nano/micro particles. Tim Scott (ChemEng) with expertise in polymer chemistry will be developing the adhesive matrix. Brian Clarkson (Dentistry) will synthesize fluorhydroxyapatite (FA) particles shown to be non-toxic and biocompatible. Emmanuelle Marquis (MSE) will interrogate the filled adhesive/bone interface using high resolution imaging techniques. A major advantage of these self etch resins is that bond strengths increase in the presence of moisture. FA particles have also been shown to be bioactive by stimulating stem cell lines to differentiate into osteoblast-like cells which produce mineral in vitro and a bone-like substance in vivo. The interface will be the critical element in establishing the success or failure of this proposed novel bone adhesive.