Intergenerational effects of iron deficiency in infancy

Project ID: 1470

Cube proposed by: Betsy Lozoff

Unit: UMOR Units

Cycle: MCubed 2.0

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About this project: 
Iron deficiency is the most common nutrient disorder in the world. To assess intergenerational effects of iron deficiency in early life, this pilot study assesses the feasibility of enrolling neonates born to young adults who participated as infants in an iron deficiency study in Chile. Examples includes effects on red cell regulation (potential epigenetic mechanisms) and parenting behavior. We also plan to pursue other new directions building on this longitudinal cohort of ~1000 young adults. Due to iron’s role in brain reward circuits, we have data on substance use in the cohort. With legalization of marijuana in Chile, we are interested in effects on the infants. Chile has been hard hit by the obesity epidemic, making the epigenetics of energy metabolism another research question. Demonstrating the feasibility of finding participants during pregnancy and collecting cord blood in a large metropolitan area will set the stage for 2-3 new NIH grants.