For the past five years, Professor Cain's research team has been developing a new technique called "Histotripsy" which is a non-invasive ultrasonic tissue fractionation approach for the treatment of benign disease and cancer. Histotripsy results in localized tissue removal with sharp boundaries, which they use to remove cardiac tissue in treatment of congenital heart disease. In bulk tissue, histotripsy produces mechanical fragmentation of tissue resulting in a liquefied core with very sharply demarcated boundaries. Histology demonstrates that treated tissue within the lesion is fragmented to subcelluar level surrounded by an almost imperceptibly narrow margin of cellular injury. Histotripsy has vast clinical applications where precise tissue ablation and removal are needed (e.g., tumor treatment).
Hempel CR, Hall TL, Cain CA, Fowlkes JB, Xu Z, Roberts WW. "Histotripsy fractionation of prostate tissue: Local effects and systemic response in a canine model." J Urol. (In Press).
Winterroth F, Xu Z, Wang TY, Wilkinson JE, Fowlkes JB, Roberts WW, Cain CA. "Examining and analyzing subcellular morphology of renal tissue treated by histotripsy". Ultrasound Med Biol, vol. 37(1), pp.78-86. 2011.
Maxwell AD, Owens G, Gurm HS, Ives K, Myers DD, Xu Z. "Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model." J. Vasc. Interv. Radiol. 2010. (In Press)
Maxwell AD, Wang TY, Yuan L, Duryea AP, Xu Z, Cain CA. "A tissue phantom for visualization and measurement of ultrasound-induced cavitation damage". Ultrasound Med Biol, vol. 36(12), pp. 2132-43, 2010.
Xu Z, Owens G, Gordon D, Cain CA, and Ludomirsky A, "Non-invasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model," Circulation, vol. 121, pp. 742-749, 2010.
Duryea AP, Hall TL, Maxwell AD, Xu Z, Cain CA, Roberts WW. "Histotripsy Erosion of Model Urinary Calculi". J Endourol. 2010. (In Press)