Michael J Imperiale

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University: 
University of Michigan - Ann Arbor
Unit: 
Medicine
Department: 
Microbiology and Immunology
Title: 
Professor
Short bio: 

Dr. Michael Imperiale is a Professor in the Department of Microbiology and Immunology at the University of Michigan Medical School. He joined the department in 1984 as the Arthur F. Thurnau Assistant Professor of Microbiology and Immunology and was subsequently promoted to Associate Professor in 1990 and Professor in 1996. He is currently the Arthur F. Thurnau Professor and Associate Chair of Microbiology and Immunology. In 2010 Dr. Imperiale was elected as a Fellow of the American Academy of Microbiology and in 2011 he was elected as a Fellow of the American Association for the Advancement of Science.

Before joining the University of Michigan, Dr. Imperiale carried out research training as a postdoctoral fellow at The Rockefeller University, where he first became interested in DNA tumor viruses, studying gene regulation in the human pathogen, adenovirus. He received his undergraduate and graduate training at Columbia University, receiving a B.A. in 1976, M.A. in 1978, and Ph.D. in 1981, all in biological sciences. Currently, Dr. Imperiale’s research interests focus on the study of how DNA tumor viruses interact with the host cell.

Dr. Imperiale is a member of the National Science Advisory Board for Biosecurity,a position he has held since 2005. He also serves as an editor of the Journal of Virology, PLos Pathogens, and mBio.

Research summary: 

Our major area of study is the interaction between the human polyomavirus, BKPyV, and the host cell. BKPyV establishes a lifelong, subclinical infection in the urinary tract. In healthy individuals, the virus replicates periodically but does not cause disease, while in renal and bone marrow transplant patients viral reactivation causes significant morbidity. For example, up to 10% of all kidney graft dysfunction is due to BKPyV replcation, which is a significant problem since there are no available antiviral drugs. We are interested in discovering how the virus is kept under control and what causes it to reactivate, and how it leads to disease when the immune system is compromised. We are also interested in how the virus traffics from the outside of the cell to the nucleus, where it replicates.

Recent publications: 

Bennett, S.M., Jiang, M., and Imperiale, M.J. (2013). Role of cell type-specific ER-associated degradation in polyomavirus trafficking. J. Virol., in press.

Broekema, N.M. and Imperiale, M.J. (2013). miRNA regulation of BK polyomavirus replication during early infection. Proc. Natl. Acad. Sci. USA 110:8200-8205.

Jiang, M., Zhao, L., Gamez, M., and Imperiale, M.J. (2012). Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection. PLoS Pathog. 8(8): e1002898. doi:10.1371/journal.ppat.1002898.

Christensen, J.B., Ewing, S.G., and Imperiale, M.J. (2012). Identification and characterization of a DNA binding domain on the adenovirus IVa2 protein. Virology 433:124–130.

Imperiale, M.J. (2012). Dual-use research after the avian influenza controversy. B. Atom. Sci. http://thebulletin.org/web-edition/op-eds/dual-use-research-after-the-av....

Bennett, S.M., Broekema, N.B., and Imperiale, M.J. (2012). BK polyomavirus: emerging pathogen. Microbes Infect. 14:672-683.

Imperiale, M.J. and Hanna, M.G. III. (2012). Biosafety considerations of mammalian-transmissible H5N1 influenza. mBio 3(2):e00043-12. doi:10.1128/mBio.00043-12.

Jiang, M. and Imperiale, M.J. (2012). Design stars: how small DNA viruses remodel the host nucleus. Future Virol. 7:445-459.

Berns, K.I., Casadevall, A., Cohen, M.L., Ehrlich, S.A., Enquist, L.W., Fitch, J.P., Franz, D.R., Fraser-Liggett, C.M., Grant, C.M., Imperiale, M.J., Kanabrocki, J., Keim, P.S., Lemon, S.M., Levy, S.B., Lumpkin, J.R., Miller, J.F., Murch, R., Nance, M.E., Osterholm, M.T., Relman, D.A., Roth, J.A., and Vidaver, A.K. (2012). Public health and biosecurity. Adaptations of avian flu virus are a cause for concern. Science 335:660-661.

Broekema, N.M. and Imperiale, M.J. (2012). Efficient propagation of archetype BK and JC polyomaviruses. Virology 422:235-241.

Imperiale, M.J. and Casadevall, A. (2011). Bioterrorism: Lessons learned since the anthrax mailings. mBio 2(6):e00232-11. doi:10.1128/mBio.00232-11.

Broekema, N.M., Abend, J.R., Bennett, S.M., Butel, J.S., Vanchiere, J.A., and Imperiale, M.J. (2010). A system for the analysis of BKV non-coding control regions: application to clinical isolates from an HIV/AIDS patient. Virology 407:368–373.

Jiang, M., Entezami, P., Gamez, M., Stamminger, T., and Imperiale, M.J. (2011). Functional reorganization of promyelocytic leukemia nuclear bodies during BK virus infection. mBio 2(1):e00281-10. doi:10.1128/mBio.00281-10.

Imperiale, M.J. and Enquist, L.W. (2011). What’s in a name? J. Virol. 85:5245.

Broekema, N.M., Abend, J.R., Bennett, S.M., Butel, J.S., Vanchiere, J.A., and Imperiale, M.J. (2010). A system for the analysis of BKV non-coding control regions: application to clinical isolates from an HIV/AIDS patient. Virology 407:368–373.

Casadevall A, Imperiale MJ. (2010). Destruction of microbial collections in response to select agent and toxin list regulations. Biosecur Bioterror 8:151-154.

Swimm AI, Bornmann W, Jiang M, Imperiale MJ, Lukacher AE, Kalman D. (2010). Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus. J Virol 84:4243-4251.

Abend JR, Low JA, Imperiale MJ. (2010). Global effects of BKV infection on gene expression in human primary kidney epithelial cells. Virology 397:73-79.

Tseng-Rogenski SS, Arredouani MS, Escara-Wilke JF, Neeley YC, Imperiale MJ, Sanda MG. (2009). A safety-modified SV40 Tag developed for human cancer immunotherapy. Drug Des Devel Ther 2:17-24.

Franz DR, Ehrlich SA, Casadevall A, Imperiale MJ, Keim PS. (2009). The "nuclearization" of biology is a threat to health and security. Biosecur Bioterror 7:243-244.

Abend JR, Jiang M, Imperiale MJ. (2009). BK virus and human cancer: innocent until proven guilty. Semin Cancer Biol 19:252-260.

Mahon C, Liang B, Tikhanovich I, Abend JR, Imperiale MJ, Nasheuer HP, Folk WR. (2009). Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts. J Virol 83:5708-5717.

Abend JR, Joseph AE, Das D, Campbell-Cecen DB, Imperiale MJ. (2009). A truncated T antigen expressed from an alternatively spliced BK virus early mRNA. J Gen Virol 90:1238-1245.

Jiang M, Abend JR, Tsai B, Imperiale MJ. (2009). Early events during BK virus entry and disassembly. J Virol 83:1350-1358.

Jiang M, Abend JR, Johnson SF, Imperiale MJ. (2009). The role of polyomaviruses in human disease. Virology 384:266-273.