Jorge A Iniguez-Lluhi

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University: 
University of Michigan - Ann Arbor
Unit: 
Medicine
Department: 
Pharmacology
Title: 
Associate Professor 
Short bio: 

Ph.D. University of Texas Southwestern Medical Center Dallas, TX.

Postdoctoral Fellow, University of California San Francisco

Research summary: 

My research interests include protein regulation by Ubiquitin-like post-translational modifications; Mechanism of action and pathobiology of steroid hormone receptors; Basic mechanisms of transcriptional regulation; Drug discovery and development.

Recent publications: 

Chua, J.P., Reddy, S.L., Yu, Z., Giorgetti, E., Montie, H.L., Mukherjee, S., Higgins, J., McEachin, R.C., Robins, D.M., Merry, D.E., et al. 2015. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease. The Journal of Clinical Investigation 125:831-845.

Højfeldt, J.W., Cruz-Rodríguez, O., Imaeda, Y., Van Dyke, A.R., Carolan, J.P., Mapp, A.K., and Iñiguez-Lluhí, J.A. 2014. Bifunctional Ligands Allow Deliberate Extrinsic Reprogramming of the Glucocorticoid Receptor. Molecular Endocrinology 28:249-259.

Druker, J., Liberman, A.C., Antunica-Noguerol, M., Gerez, J., Paez-Pereda, M., Rein, T., Iniguez-Lluhi, J.A., Holsboer, F., and Arzt, E. 2013. RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity. Mol Cell Biol 33:2116-2127.

Mukherjee, S., Cruz-Rodriguez, O., Bolton, E., and Iniguez-Lluhi, J.A. 2012. The in Vivo Role of Androgen Receptor SUMOylation as Revealed by Androgen Insensitivity Syndrome and Prostate Cancer Mutations Targeting the Proline/Glycine Residues of Synergy Control Motifs. J Biol Chem 287:31195-31206.

 Danciu, T.E., Chupreta, S., Cruz, O., Fox, J.E., Whitman, M., and Iñiguez-Lluhí, J.A. 2012. Small Ubiquitin-like Modifier (SUMO) Modification Mediates Function of the Inhibitory Domains of Developmental Regulators FOXC1 and FOXC2. J Biol Chem 287:18318-18329.

Snider, N.T., Weerasinghe, S.V.W., Iñiguez-Lluhí, J.A., Herrmann, H., and Omary, M.B. 2011. Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. Journal of Biological Chemistry 286.

Subunit-dependent axonal trafficking of distinct alpha heteromeric potassium channel complexes. J Neurosci 31:13224-13235.

 Yang, W.H., Heaton, J.H., Brevig, H., Mukherjee, S., Iñiguez-Lluhí, J.A., and Hammer, G.D. 2009. SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation. Molecular and Cellular Biology 29:613-625.

Mukherjee, S., Thomas, M., Dadgar, N., Lieberman, A.P., and Iniguez-Lluhi, J.A. 2009. Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation. J Biol Chem 284:21296-21306.

 Iñiguez-Lluhí, J.A. 2009. Control of Transcription by SUMO modification. In SUMO Regulation of Cellular Processes. V.G. Wilson, editor: Springer Verlag. 13-40.

Figueroa-Romero, C., Iñiguez-Lluhí, J.A., Stadler, J., Chang, C.R., Arnoult, D., Keller, P.J., Hong, Y., Blackstone, C., and Feldman, E.L. 2009. SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. Faseb J.

Benson, M.D., Iñiguez-Lluhí, J.A., and Martens, J.R. 2009. Regulation of Voltage-Gated Potassium Channels through SUMO Modification. In SUMO Regulation of Cellular Processes. V.G. Wilson, editor: Springer Verlag.

 Ceseña, T.I., Cui, T.X., Subramanian, L., Fulton, C.T., Iñiguez-Lluhí, J.A., Kwok, R.P.S., and Schwartz, J. 2008. Acetylation and Deacetylation of CCAAT/Enhancer Binding Protein b at K39 Alters its Ability to Regulate Transcription of Adipocyte Genes. Molecular and Cellular Endocrinology 289:94-101.

Keywords: 
Protein modification,
drug discovery,
pharmacology,
Nuclear receptor,
SUMO,
Polyglutamine,
Neurodegeneration,
Ubiquitin-like,
cardiovascular,
gene regulation,
Hormone,
AGlucocorticoid,
Androgen,
prostate cancer