Jeffrey W Innis

innis's picture
No Tokens Left in Unit
University: 
University of Michigan - Ann Arbor
Unit: 
Medicine
Department: 
Human Genetics
Title: 
Professor
Short bio: 

Education:

1988-91 Baylor College of Medicine Genetics Fellowship

1985-88 Baylor College of Medicine Pediatric Residency

1985 University of Miami School of Medicine, Miami, FL, M.D.

1983 University of Micami School of Medicine, Miami, FL, Ph.D. Biochemistry

1980 Floria Atlantic University, Boca Raton, FL, B.S. Biology

Research summary: 

His research interests include Early Post-Implantation Mammalian Body Patterning

Recent publications: 

Lehoczky J, Innis JW. BAC transgenic analysis reveals enhancers sufficient for Hoxa13 and neighborhood

gene expression in mouse embryonic distal limbs and genital bud. Evolution & Development, 2008,

IN PRESS.

 

Lehoczky J, Innis JW. Expanded Hoxa13 Polyalanine Tracts in the Monotreme. Evolution & Development,

2008, IN PRESS.

 

Williams ME, Lehoczky JA, Innis JW. A group 13 homeodomain is neither necessary nor sufficient for posterior prevalence in the mouse limb. Developmental Biology 2006, 297: 493-507.

 

Lahidji SF, Buchman SR, Muraszko K, Innis JW, Keegan CE. Craniofacial Dyssynostosis in Two Boys with Apparently Normal Cognitive Development. Amer J Med Gen 2006, 140(12):1333-6.

 

Lehoczky J, Cai W-W, Douglas J, Moran J, Beier D, Innis JW. Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations. Mammalian Genome 2006, 17(9):903-13 (Cover).

 

DeScipio C, Kaur M, Yaeger D, Davis R, Innis JW, Spinner NB, Jackson LG, Krantz ID. Chromosome rearrangements in Cornelia de Lange syndrome (CdLS): Report of a Der(3)t(3;12)(p25.3;p13.3) in two half sibs with features of CdLS and review of reported CdLS cases with chromosome rearrangements. Am. J. Med. Gen., 2005, 137A: 276-282.

 

McDermott DA, Bressan MA, He J, Lee JS, Aftimos S, Brueckner M, Gilbert F, Graham GE, Innis JW, Pierpont MEM, Raas-Rothschild A, Shanske AL, Smith WE, Spencer RH, St. John-Sutton MG, van Maldergem L, Waggoner DJ, Basson CT. TBX5 genetic testing validates strict clinical criteria for Holt-Oram syndrome. Pediatric Research, in press; PMID: 16183809.

 

Misra VK, Struys EA, O'Brien W, Salomons GS, Glover T, Jakobs C, Innis JW. Phenotypic heterogeneity in the presentation of D-2-hydroxyglutaric aciduria in monozygotic twins. Molecular Genetics and Metabolism, 2005, 86: 200-205.

 

Williams TM, Williams ME, Heaton JH, Gelehrter TD, Innis JW. Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA binding capability. Nucleic Acids Research, 2005, 33: 4475-84.

 

McCabe C, Innis JW. A genomic approach to identification and characterization of

HOXA13 functional binding elements. Nucleic Acids Research, 2005, 33:6782-94.

 

Williams T, Williams ME, Innis JW. Range of HOX/TALE Superclass Associations and Protein

Domain Requirements for HOXA13/MEIS Interaction. Developmental Biology, 2005, 277:457-471.

 

Innis JW, Mortlock DP, Chen Z, Ludwig M, Williams ME, Williams TM, Doyle CD, Shao Z, Glynn

M, Mikulic D, Lehmann K, Mundlos S, Utsch B. Polyalanine expansion in HOXA13: Three new affected families and the molecular consequences in a mouse model. Human Molecular Genetics, 2004, 13:2841-2851.

 

Williams TM, Williams ME, Kuick R, Misek D, McDonagh K, Hanash S, Innis JW. Candidate downstream-regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability. Developmental Biology, 2005, 279: 462-480.

 

Lehoczky JA, Williams ME, Innis JW. Conserved Expression Domains For Genes Upstream and

Within of HoxA and HoxD Clusters Suggests a Long-range Enhancer Existed Prior to Cluster Duplication. 2004, Evolution and Development, 2004, 6:423-430.

 

Keegan CE, Vilain E, Mohammed M, Lehoczky J, Dobyns WB, Archer SM, Innis JW.

Microcephaly, jejunal atresia, aberrant right bronchus, ocular anomalies, and XY sex reversal.. Am. J. Med. Gen. 2004, 125: 293-298.

 

Wechsler SB, Lehoczky JA, Hall JG, Innis JW. Tibial aplasia and preaxial polydactyly,

brachyphalangy, craniofacial dysmorphisms and genital hypoplasia: Further delineation and mutational analysis. Clinical Dysmorphology, 2004, 13: 63-69.

 

Innis JW, Goodman F, Williams T, Mortlock D, Sateesh P, McKinnon W, Guttmacher A.

A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome. Human Mutation, 2002, 19: 573-574.

 

Margulies EH, Kardia SLR, Innis JW. Identification and prevention of a GC content bias in SAGE

libraries. Nucleic Acids Res. 2001, 29 (12): e60.

 

Margulies EH, Kardia SLR, Innis JW. A comparative molecular analysis of developing

mouse forelimbs and hindlimbs using serial analysis of gene expression (SAGE). Genome Research 2001, 11: 1686-1698.

 

Post LC, Margulies EH, Kuo A, Innis JW. Severe limb defects in Hypodactyly mice result from

expression of a novel, mutant HOXA13 protein. Developmental Biology 2000, 217: 290-300.

 

Mortlock DP, Sateesh P, Innis JW. Evolution of N-terminal sequences of the vertebrate HOXA13

protein. Mammalian Genome 2000, 11: 151-158.

 

Goodman FR, Fryns J-P, Mortlock DP, Innis JW, Holmes LB, Donnenfeld AE, Feingold M, Beemer

FA, Hennekam RCM, Scambler PJ. Novel HOXA13 mutations and the phenotypic spectrum of Hand-Foot-Genital Syndrome. Amer. J. Hum. Gen. 2000, 67: 197-202.

 

Margulies EH, Innis JW. eSAGE: Managing and analyzing data generated with Serial Analysis of

Gene Expression (SAGE). Bioinformatics 2000, 16: 649-650.

 

Post LC and Innis JW. Altered Hox expression and increased cell death distinguish Hypodactyly

from Hoxa13 null mice. Int. J. Dev. Biol. 1999, 43: 287-294.

 

Post LC and Innis JW. Infertility in Hypodactyly mice is associated with hypoplasia of distal reproductive structures. Biology of Reproduction 1999, 61: 1402-1408.

 

Mortlock DP and Innis JW. Mutation of HOXA13 in Hand-foot-genital syndrome. Nature Genetics

1997, 15: 179-180.

 

Kondo T, Zakany J, Innis JW, and Duboule D. Of fingers, toes and penises. Nature 1997, 390: 29.

 

Mortlock DM, Nelson M, and Innis JW. An efficient method for isolating putative promoters and 5'

transcribed sequences from large genomic clones. Genome Research, 1996, 6: 327-335.

 

Mortlock DP, Post LC, and Innis JW. The Molecular Basis of Hypodactyly (Hd): A Deletion in

Hoxa13 Leads to Arrest of Digital Arch Formation. Nature Genetics 1996, 13: 284-289.