Jianping Fu

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University: 
University of Michigan - Ann Arbor
Unit: 
Engineering
Department: 
Mechanical Engineering
Title: 
Assistant Professor, Mechanical Engineering; Assistant Professor, Biomedical Engineering
Phone: 
(734) 615-7363
Short bio: 

Ph.D. Massachusetts Institute of Technology. 2007.

M.S. University of California, Los Angeles. 2002.

B.E. University of Science and Technology of China. 2000.

Research summary: 

Our group's interests lie at the nexus of micro/nanoengineering, biophysics, biology, and biotechnology.  Currently, we focus on developing integrated systems for high throughput quantitative micro/nanoscale analysis of molecular and cellular functions.  Specifically, we are developing integrated techniques to investigate biological entities (from nanoscale biomolecules to micron-sized mammalian cells) confined in micro/nanofluidic environments. We study molecular and cellular interactions with these micro/nanofluidic structures and explore the opportunity of using these micro/nanofluidic devices for ultra-sensitive biosensing and detection as well as for efficient biosample preparation.  We are also interested in developing synthetic micro/nanoscale cellular microenvironment to direct cellular behaviors, and further employing them to identify the extrinsic physical factors and their downstream signaling pathways that regulate cell functions.

Recent publications: 

[1]           Jianping Fu, Reto B. Schoch, Anna L. Stevens, Steven R. Tannenbaum, and Jongyoon Han.  A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins.  Nature Nanotechnology, vol. 2, pp.121-128, 2007.  PMCID: PMC2621439.

[2]           Jianping Fu, Yang-Kao Wang, Michael T. Yang, Ravi A. Desai, Xiang Yu, Zhijun Liu, and Christopher S. Chen.  Mechanical regulation of cell function with geometrically modulated elastomeric substrates.  Nature Methods, vol. 7, pp.733-736, 2010.  PMCID: PMC3069358.

[3]           Shinuo Weng, and Jianping Fu.  Synergistic regulation of cell function by matrix rigidity and adhesive pattern.  Biomaterials, vol. 32, pp. 9584-9593, 2011.  (PMC Journal - In process)

[4]           Jennifer M. Mann, Raymond Hiu-Wai Lam, Shinuo Weng, Yubing Sun, and Jianping Fu.  A silicone-based stretchable micropost array membrane for monitoring live-cell subcellular cytoskeletal response.  Lab on Chip, vol. 12, pp. 731-740, 2012.  (PMC Journal - In process)

[5]           Weiqiang Chen, Luis G. Villa-Diaz, Yubing Sun, Shinuo Weng, Raymond Hiu-Wai Lam, Paul H. Krebsbach, and Jianping Fu.  Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells.  ACS Nano, vol. 6, pp. 4094-4103, 2012.  PMCID: PMC3358529.

[6]           Yubing Sun, Luis G. Villa-Diaz, Raymond Hiu-Wai Lam, Weiqiang Chen, Paul H. Krebsbach, and Jianping Fu.  Matrix mechanics regulates fate decisions of human embryonic stem cells.  PLoS ONE, vol. 7, e37178, 2012.  PMCID: PMC3353896.

[7]           Raymond Hiu-Wai Lam, Shinuo Weng, Wei Lu, and Jianping Fu.  Live-cell subcellular measurement of cell stiffness using a microengineered stretchable micropost array membrane.  Integrative Biology, vol. 4, pp. 1289-1298, 2012.  PMCID: PMC4088946.

[8]           Yubing Sun, and Jianping Fu.  Mechanobiology: A new frontier for human pluripotent stem cells.  Integrative Biology, vol. 5, pp. 450-457, 2013.  (PMC Journal - In process)

[9]           Ankur Singh, Shalu Suri, Ted T. Lee, Jamie M.Chilton, Weiqiang Chen, Jianping Fu, Steven L. Stice, Hang Lu, Todd C. McDevitt, and Andrés J. García.  Adhesive signature-based, label-free isolation of human pluripotent stem cells.  Nature Methods, vol. 10, pp. 438-444, 2013.  PMCID: PMC3641175.

[10]        David W. Dumbauld, Ted T. Lee, Ankur Singh, Jan Scrimgeour, Charles A. Gersbach, Evan A. Zamir, Jianping Fu, Christopher S. Chen, Jennifer E. Curtis, Susan W. Craig, and Andrés J. García.  How vinculin regulates traction forces and adhesion strength. Proc Natl Acad Sci USA, vol. 110, pp. 9788-9793, 2013.  PMCID: PMC3683711.

[11]        Zhenzhen Fan, Yubing Sun, Di Chen, Weiqiang Chen, Cheri Deng, and Jianping Fu.  Acoustic tweezing cytometry for live-cell subcellular control of intracellular cytoskeleton contractility.  Scientific Reports, vol. 3, 2176, 2013.  PMCID: PMC3709169.

[12]        Yue Shao, and Jianping FuIntegrating micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: A materials perspective.  Advanced Materials, vol. 6, pp. 300-311, 2014.  PMCID: PMC4076293.

[13]        Yue Shao, Jennifer M. Mann, Weiqiang Chen, and Jianping Fu.  Global architecture of F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction.  Integrative Biology, vol. 6, pp. 300-311, 2014.  PMCID: PMC3963173.

[14]        Yubing Sun, Koh Meng Aw Yong, Luis G. Villa-Diaz, Xiaoli Zhang, Weiqiang Chen, Renee Philson, Shinuo Weng, Haoxing Xu, Paul H. Krebsbach, and Jianping Fu.  Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells.  Nature Materials, vol. 13, pp. 599-604, 2014.  PMCID: PMC4051885.

[15]        Yubing Sun, and Jianping Fu.  Harnessing mechanobiology of human pluripotent stem cells for regenerative medicine.  ACS Chemical Neuroscience, in press, 2014.  (DOI: 10.1021/cn5001155) (PMC Journal - In process)

Keywords: 
mechanobiology,
Mechanotransduction,
Stem Cell Biology,
bioengineering,
BioMEMS
Delegates: 
jpfu