Sundeep Kalantry

kalantry's picture
University: 
University of Michigan - Ann Arbor
Unit: 
Medicine
Department: 
Human Genetics
Title: 
Associate Professor
Phone: 
734 615 9578
Short bio: 

Postdoctoral Fellowship, 2002-2009

University of North Carolina, Chapel Hill

Ph.D., Cell Biology and Genetics/Molecular Biology, 1995-2001

Weill Graduate School of Medical Sciences of Cornell University, New York, NY

B.A., Biochemistry, 1989-93

Cornell University, Ithaca, NY

Research summary: 

His research aims to define the epigenetic mechanisms that regulate X-chromosome inactivation, which results in transcriptional silencing of most genes along one of the two X-chromosomes in female mammals.

Recent publications: 

Kalantry S and Mueller. Mary Lyon: A Tribute. Americal Journal of Human Genetics. 2015 October 1 97(4):507-511.

Hinten M, Maclary E, Gayen S, Harris C, Kalantry S. Visualizing Long Non-coding RNAs on Chromatin. Methods in Molecular Biology. 2016. (In Press)

Ku C-J, Lim K-C, Kalantry S, Maillard I, Engel JD, Tomonori H: A mon- to biallelic T cell transcriptional switch regulates GATA3 abundance. Genes & Development. 2015 Sep 15;29(18):1930-41. 

Sarkar MK, Gayen S, Kumar S, Maclary E, Buttigieg E, Hinten M, Kumari A, Harris C, Sado T, Kalantry S. An Xist Activating Antisense RNA Required for X-chromosome Inactivation. Nature Communications. 2015. (In Press)

Kang, J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, and Rao A. Simultaneous deletion of Tet1 and Tet3 increases transcriptional variability in early embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2015. PubMed PMID: 26199412.

Gayen S, Maclary E, Buttigieg E, Hinten M, Kalantry S. A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation. Cell Reports. 2015 May 26;11(8):1251-65. 

Maclary E, Buttigieg E, Hinten M, Gayen S, Harris C, Sarkar MK, Purushothaman S, and Kalantry S. Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation. Nature Communications, 5:4209, 2014.

Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, Poliakov A, Yocum AK, Li Y, Chen W, Cao X, Jiang X, Dahiya A, Harris C, Feng FY, Kalantry S, Qin ZS, Dhanasekaran SM, and Chinnaiyan AM. The central role of EED in the orchestration of Polycomb Group complexes. Nature Communications, 5: 3127, 2014. 

Maclary E, Hinten M, Harris C, and Kalantry, S. Long noncoding RNAs in the X-inactivation center. Chromosome Research, 21(6-7): 601-614, 2013. 

Kang J, Kalantry S, and Rao A. PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes. Cell Research, 23(1): 6-9, 2013.

Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin JD, Lu S, Byron M, Kalantry S, Mercurio A, Lawrence JB, Hoffmann A, Bach I.  Paternal RLIM/Rnf12 is a survival factor for milk producing alveolar cells.  Cell, 149 (3): 630-641.  Jiao et al., 2012.pdf

Williams LH, Kalantry S, Starmer J, Magnuson T.  Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass.  Development, 226 (7): 1714-1718.  Development 2011 Williams.pdf

Kalantry S. Recent advances in X-chromosome inactivation.  J. Cell. Physiol., 226 (7): 1714-1718, 2011.  Kalantry, S. 2011.pdf

Kalantry S, Purushothaman S, Bowen Randall B, Starmer J, Magnuson T.  Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation., Nature, 460  (7255): 647-651, 2009. Kalantry et al., 2009.pdf   Supplement.pdf

Alexander MK, Mlynarczyk-Evans S, Royce-Tolland M, Plocik A, Kalantry S, Magnuson T, Panning B.  Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed.  J Cell Biol, 179(2):269-276, 2007.  Alexander et al., 2007.pdf 

Keywords: 
Epigenetics,
Chromatin,
histone modifications,
non-coding RNAs,
X-chromosome inactivation,
Polycomb group