Longchuan Bai

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University of Michigan - Ann Arbor
Internal Medicine- Hematology/Oncology
Research Assistant Professor
Short bio: 


1991       B.S., Beijing Normal University, Beijing, China

1994       M.S., Beijing Normal University, Beijing, China

1997       Ph.D., Peking Union Medical College, Beijing. Dissertation: "Transcriptional regulation of human immunodeficiency vrus type 1 gene expression by Tat transactivator." (Advisor: Boqin Qiang, M.D.)

1997-2000            Postdoctoral Associate, Howard Hughes Medical Institute, Ann Arbor, MI (Mentor: Juanita L. Merchant, M.D., Ph.D.)

2000-2002            Research Fellow, University of Michigan, Ann Arbor, MI (Mentor: Juanita L. Merchant, M.D., Ph.D.)

Research summary: 

His research interests include a molecular approach to cancer prevention and treatment and mechanisms of action of small molecular inhibitors in apoptosis induction

Recent publications: 

Chen J, Bai L, Bernard D, Nikolovska-Coleska Z, Gomez C, Zhang J, Yi H, Wang S. Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. ACS Med Chem Lett, 2010 May 13; 1(2):85-89. (PMID 20596242)  PMC 2892918.

Yang J, McEachern D, Li W, Davis MA, Li H, Morgan MA, Bai L, Sebolt JT, Sun H, Lawrence TS, Wang S, Sun Y.  Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases. Mol Cancer Ther, 2011 Apr; 10(4):658-669. (PMID 21282353)  PMC 3073022.

Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S.  Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment. Mol Cancer Ther, 2011 May; 10(5):902-914. (PMID 21372226)  PMC 3091962.

Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. J Med Chem, 2011 May 12; 54(9):3306-3318. (PMID 21462933)  PMC 3108148.

Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S.  LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFalpha expression and receptor tyrosine kinase signaling. Cancer Res, 2012 Mar 1; 72(5):1229-1238. (PMID 22241084)  PMC 3294058.

Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. J Med Chem, 2012 May 24; 55(10):4664-4682. (PMID 22448988) PMC 3397176.

Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Correction to Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. J Med Chem, 2012 Jun 28; 55(12):5987. (PMID 22676037)  PMC 3417240.

Zhou H, Aguilar A, Chen J, Bai L, Liu L, Meagher JL, Yang CY, McEachern D, Cong X, Stuckey JA, Wang S. Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity. J Med Chem, 2012 Jul 12; 55(13):6149-6161. (PMID 22747598)  PMC 3417242.

Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem, 2012 Oct 11; 55(19):8502-8514. (PMID 23030453)  PMC 3495162.

Wang S, Bai L, Lu J, Liu L, Yang CY, Sun H.  Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. J Mammary Gland Biol Neoplasia, 2012 Dec; 17(3-4):217-228. (PMID 23054134)  PMC 3534930.

Aguilar A, Zhou H, Chen J, Liu L, Bai L, McEachern D, Yang CY, Meagher J, Stuckey J, Wang S. A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem, 2013 Apr 11; 56(7):3048-3067. (PMID 23448298).

El-Zaatari M, Kao JY, Tessier A, Bai L, Hayes MM, Fontaine C, Eaton KA, Merchant JL.  Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One, 2013; 8(3):e58935. (PMID 23520544)  PMC 3592845.

Bai L and Wang S. Targeting Apoptosis Pathways for New Cancer Therapeutics. Ann Rev Med 2014; 65:139-155. doi: 10.1146/annurev-med-010713-141310. Epub 2013 Nov 4. (PMID 24188661)

Bai L, Smith DC, Wang S. Small-molecule SMAC mimetics as new cancer therapeutics. Pharmacol Ther. 2014 Oct;144(1):82-95. doi: 10.1016/j.pharmthera.2014.05.007. Epub 2014 May 16. Review. (PMID 24841289)

Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, Wang S. BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo. PLoS ONE 2014 Jun 5; 9(6): e99404. doi: 10.1371/journal.pone.0099404. eCollection 2014. (PMID 24901320) PMC 4047118