Louis G. D'Alecy

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University: 
University of Michigan - Ann Arbor
Unit: 
Medicine
Department: 
Molecular and Integrative Physiology
Title: 
Professor
Short bio: 

He is a classical Professor of Physiology, who loves to work at the bench at mechanistically challenging in vivo and in vitro experimentation. As Sequence Director for the Cardiovascular and Respiratory Sequences for 1ST year Medical Students he spends a lot of time in the classroom. He directs the telemetry core facility making available continuous conscious monitoring of blood pressure and ECG in mice and rats.

Research summary: 

My specific research tends toward the vascular side of the cardiovascular system. I want to develop a better understanding of how blood vessels and blood flow are controlled in health and in disease. New chemicals and pathway are being identified every day as contributors the cardiovascular risk that that makes heart and vascular disease a leading cause of morbidity and mortality. While “special circulations” such as the brain (cerebral) and heart (coronary) receive the greatest attention from both clinicians and researchers I look to the generality of vascular disease that can cripple or incapacitate virtually any tissue or organ in the body be it a painful cramp in a leg or a failing kidney. Dysfunction of blood flow control systems tend to have common elements and by uncovering the generalizeable basic control systems and their failures the potential for a more holistic good for the cardiovascular system may be obtained. 

Recent publications: 

Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Mortensen RM. Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Physiol Meas 2007; 28(11): 1329‑1339. 



Fomicheva E, Turner I, Edwards TG, Hoff J, Arden E, D’Alecy LG and  Metzger JM. Double oxygen sensing vector system for robust hypoxia/ischemia- 

regulated gene induction in cardiac muscle in vitro and in vivo. Molecular Therapy, xx: May XXX-XXX, 2008 



Crozier SJ, Sans MD, Lang CH, D’Alecy LG, Ernst SA, Williams JA. CCK‑induced pancreatic growth is not limited by mitogenic capacity in mice. Am J Physiol, 294:G1148‑G1157, 2008