J. Michelle Kahlenberg

mkahlenb's picture
No Tokens Left in Unit
University: 
University of Michigan - Ann Arbor
Unit: 
Medicine
Department: 
Internal Medicine, Division of Rheumatology
Title: 
Assistant Professor 
Phone: 
734-615-1880
Short bio: 

M.D. 2006.

Ph.D. 2004.

B.S. 1998.

Research summary: 

My research encompasses understanding the role of innate immunity in autoimmune disease development.  Currently, I am interested in understanding the role of the inflammasome and its production of the pro-inflammatory cytokine IL-18 in lupus nephritis, cutaneous lupus and the enhanced risk of cardiovascular disease seen in lupus patients.  This is undertaken through molecular biology, murine model and systems biology approaches. I am also interested in developing a research program encompassing how autoimmune diseases contribute to the development of eye inflammation.

Recent publications: 

Kahlenberg JM, Thacker SG, Berthier CC, Cohen CD, Kretzler M, and Kaplan MJ.  Inflammasome Activation of IL-18 Results in Endothelial Progenitor Cell Dysfunction in Systemic Lupus Erythematosus.  Journal of Immunology 2011; 187:6143-56.

Kahlenberg JM, Kaplan MJ. The Interplay of Inflammation and Cardiovascular Disease in Systemic Lupus Erythematosus.  Arthritis Research and Therapy 2011; 13:203-212.

Kahlenberg JM, Fox DA.  Advances in the Medical Treatment of Rheumatoid Arthritis.  Hand Clinics of North America 2011; 27(1):11-20.

Kahlenberg JM.  Neuromyelitis Optica Spectrum Disorder as an Initial Presentation of Primary Sjögren’s Syndrome.  Seminars in Arthritis and Rheumatism 2011; 40(4):343-8.

Keywords: 
Innate immunity,
inflammasome,
IL-18,
IL-1,
autoimmune disease,
lupus