My research encompasses understanding the role of innate immunity in autoimmune disease development. Currently, I am interested in understanding the role of the inflammasome and its production of the pro-inflammatory cytokine IL-18 in lupus nephritis, cutaneous lupus and the enhanced risk of cardiovascular disease seen in lupus patients. This is undertaken through molecular biology, murine model and systems biology approaches. I am also interested in developing a research program encompassing how autoimmune diseases contribute to the development of eye inflammation.
Kahlenberg JM, Thacker SG, Berthier CC, Cohen CD, Kretzler M, and Kaplan MJ. Inflammasome Activation of IL-18 Results in Endothelial Progenitor Cell Dysfunction in Systemic Lupus Erythematosus. Journal of Immunology 2011; 187:6143-56.
Kahlenberg JM, Kaplan MJ. The Interplay of Inflammation and Cardiovascular Disease in Systemic Lupus Erythematosus. Arthritis Research and Therapy 2011; 13:203-212.
Kahlenberg JM, Fox DA. Advances in the Medical Treatment of Rheumatoid Arthritis. Hand Clinics of North America 2011; 27(1):11-20.
Kahlenberg JM. Neuromyelitis Optica Spectrum Disorder as an Initial Presentation of Primary SjÃ¶grenâ€™s Syndrome. Seminars in Arthritis and Rheumatism 2011; 40(4):343-8.