Nisha J. D'Silva

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University: 
University of Michigan - Ann Arbor
Unit: 
Dentistry
Department: 
Periodontics and Oral Medicine
Title: 
Donald A. Kerr Collegiate Professor of Oral Pathology; Associate Chair, Division of Oral Medicine/Pathology/Radiology; Professor, School of Dentistry; Professor of Pathology, Medical School
Phone: 
734-764-1543
Short bio: 

Ph.D. University of Washington. 1997.

M.S.D. Indiana University. 1990.

B.D.S. (D.D.S.) University of Bombay, India. Dentistry. 1987.

Research summary: 

Oral carcinogenesis: the role of ras-like proteins and galanin receptors in tumor growth and progression, focused on cell-matrix interactions as well as nuclear transport of proteins that induce transcription of genes that promote cell proliferation and invasion; identification of serum-based biomarkers for early detection of oral cancer using both basic cell and molecular biology approaches as well as translational/patient data.

Recent publications: 

Russo N, Wang X, Liu M, Banerjee R, Goto M, Scanlon C, Metwally T, Inglehart R, Tsodikov A, Duffy S, van Tubergen E, Bradford C, Carey T, Wolf G, Chinnaiyan AM, and D’Silva NJ. A novel approach to biomarker discovery in head and neck cancer using an autoantibody signature. Oncogene, In Press; October 2012.

Banerjee R, Mani R, Russo N, Scanlon CS, Tsodikov A, Jing X, Cao Q, Palanisamy N, Metwally T, Inglehart RC, TomlinsS, Bradford C, Carey T, Wolf G, Kalyana-Sundaram S, Chinnaiyan A, Varambally S and D’SilvaNJ. The tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma. Oncogene. 2011; 30(42):4339-49.

Zhang X, Rossa C, Liu M, Li F, D’Silva NJ, Kirkwood KL. Oral Squamous Carcinoma Cells Secrete RANKL Directly Supporting Osteolytic Bone Loss. Oral Oncology, In Press, 2012

Banerjee R, Russo N, Liu M, Van Tubergen E, and D’Silva NJ. Rap1 and its Regulatory Proteins: The tumor suppressor, oncogene, tumor suppressor gene axis in head and neck cancer. Small GTPases. 2012 Jul 1;3(3). [Epub ahead of print]

Wansom D, Light E, Thomas D, Worden F, Prince M, Urba S, Chepeha D, Kumar B, Cordell K, Eisbruch A Taylor J, Moyer J, Bradford C, D’Silva NJ, Carey T, McHugh J, Wolf G. Tumor Infiltrating Lymphocytes and Human Papillomavirus-16 Associated Oropharynx Cancer. 2011 Laryngoscope, In Press.

Van Tubergen E, Vander Broek R, Lee J, Wolf G, Carey T, Bradford C, Prince M, Kirkwood KL, and D’Silva NJ. Tristetraprolin regulates IL-6 which is correlated with tumor progression in head and neck squamous cell carcinoma. 2011 Cancer, 117(12):2677-89.

Banerjee R, Henson B, Russo N, Tsodikov A, D’Silva NJ. Rap1 mediates Galanin receptor 2-induced proliferation and survival in squamous cell carcinoma. 2011 Cellular Signalling, 23(7):1110-8.

Murdoch-Kinch CA, Russo N, Griffith S, Braun T, Eisbruch A, D’Silva NJ. Recovery of Salivary EGF in Parotid Saliva Following Parotid Sparing Radiation Therapy: A Proof of Principle Study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jan;111(1):64-70.

Zhao W, Liu M, D’Silva NJ, Kirkwood KL. Tristetraprolin Regulates IL-6 Expression Through p38 MAPK Dependent Affinity Changes with mRNA 3’UTR. J Interferon Cytokine Res. 2011 Aug;31(8):629-37.