Ursula Jakob

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University: 
University of Michigan - Ann Arbor
Unit: 
LSA: Natural Sciences
Department: 
Molecular, Cellular and Developmental Biology
Title: 
Professor
Phone: 
51286
Short bio: 

Professor Jakob is a Patricia S. Yaeger Collegiate Professor of Molecular, Cellular and Develomental Biology.

Education and Training
1986 - 1991  Diplom (equivalent to M.S.) in Biology, University of Regensburg, Germany
1991 - 1995  Ph.D. student, University of Regensburg, Regensburg, Germany, Biophysics and Physical Biochemistry Department (lab of J. Buchner, Dept. of R. Jaenicke)
1990 - 1991  Visiting Scientist (lab of R. Zimmermann), Ludwig Maximilian University, Munich, Germany
1992             Visiting Scientist (lab of C.T. Walsh), Harvard Medical School, Boston
1996 - 1998  DFG-sponsored Postdoctoral Fellow (lab of James Bardwell), University of Michigan, Ann Arbor, Biology Department
Research summary: 

Our work has contributed to a great change in perspective on the role and nature of reactive oxygen species (ROS) through: (1) our characterization of Hsp33, one of the first redox-regulated proteins identified, and an important player in the oxidative stress defense of bacteria, (2) the development of quantitative tools that have allowed us to identify redox-sensitive processes in bacteria and eukaryotes, and (3) the discovery of a link between early exposure to oxidants and aging.  The overall goal of my research program is to generate an integrated and system-wide view of the beneficial and deleterious effects of ROS. These studies have the clear potential to form the basis for the development of more powerful antimicrobials and novel antioxidant strategies.

Recent publications: 

Powis, K., Schrul, K., Tienson H., Gostimskaya, H.,  Breker, M., High, S.., Schuldiner, M., Jakob, U. and Schwappach, B. 2012. Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked. J. of Cell Science, 126: 473-483.

Brandes, N., Tienson, H.L., Lindemann, A., Vitvisky, V., Reichmann, D., Banerjee, R. and U. Jakob. 2013. Time line of redox events in aging postmitotic cells. eLIFE, e00306 * this paper was highlighted in an Insight article in eLIFE.

Winther JR and U. Jakob. 2013. Redox Control: A Black Hole for Oxidized Glutathione. Nat Chem Biol. 9: 69-70.

Gray, M.J., Wholey,W.Y., Parker, B.W., Kim, M., and U. Jakob. 2013. NemR is a Bleach-Sensing Transcription Factor. J. Biol. Chem. 288:13789-13798.

Reichmann, D. and U. Jakob. 2013. The roles of conditional disorder in redox proteins. Current Opinion in Structural Biology. 23: 436-442.

Gray, M.J., Wholey, W.-Y. and U. Jakob. 2013. Bacterial Responses to Reactive Chlorine Species. Annual Review in Microbiology. In press.

Cremers, C. and U. Jakob. 2013. Oxidant Sensing by Reversible Disulfide Bond Formation. J. Biol. Chem. In press.

Müller A, Hoffmann JH, Meyer HE, Narberhaus F, Jakob U. and L.I. Leichert. 2013. Non-native disulfide bond formation activates the σ32-dependent heat shock response in Escherichia coli. J. Bact. 195: 2807-2816.

Keywords: 
Oxidative stress,
Redox Regulation,
Bleach,
chaperones,
Protein Folding