Ph.D. University of Eastern Finland (Kuopio), Finland. Biochemistry. 1991.
M.Sc. University of Kuopio, Finland. Biochemistry. 1986.
B.S. University of Kuopio, Finland. Biochemistry. 1984.
Dr. Kaartinen’s laboratory is interested in underlying molecular reasons that lead to a formation of common craniofacial and cardiac birth defects in human newborn babies. Their particular interest is in TGF-beta/BMP superfamily signaling. They have a long history of using gene targeting in mouse ES cells and subsequent generation of knockout, knockin and conditional/tissue-specific knockout mice, which form a primary research model in their research laboratory.
Dr. Kaartinen’s laboratory is currently investigating a role TGF-beta superfamily signaling in lip fusion, and differentiation and anterior-posterior patterning of the palatal epithelium, regulation of TGF-beta3 expression in the palatal epithelium and the role of TGF-beta3 signaling in the palatal mesenchyme. Moreover, they currently study the role of a novel negative regulator of TGF-beta signaling (Trim33) in craniofacial development, and they have a project to identify micro-RNAs that regulate gene expression in the prefusion palatal epithelium.
Studies on cardiac development include investigations on a role of TGF-beta signaling via the Alk5 receptor in the epicardium, the role of Alk2 mediated signaling in outflowt tract and aortic valve development, and BMP type I receptor signaling interactions in atrio-ventricular canal transformation.