Anti-Infectious Nanoparticle Scaffolds
There are many challenges in the area of developing wound dressings for complex wounds. Cell therapies have been among the most promising strategies in this area, but their broader application to infected wounds has been hampered by a number of aspects beyond their high cost. Healing in infectious wounds is very complex and a number of processes occur that ultimately challenge the survival any cells infused into the wound. In this respect, nanoparticles may act as an alternative that can be involved in a number of catalytically events that may ultimately mitigate the hostile response of infected wounds. For instance, silver and copper nanoparticles are effective in releasing antimicrobial metal ions. Other nanoparticles may catalytically generate important biological mediators, such as nitric oxide or carbon monoxide. This project is designed to incorporate biofunctional nanoparticles in polymer-based wound dressing scaffolds and test them in vitro in a number of model organisms.