Cellular Models for Bipolar Disorder using Induced Pluripotent Stem Cells
Bipolar disorder is a chronic, severe psychiatric illness about which little is known about its specific pathogenesis, etiology, anatomical or cellular substrates. There is a critical unmet need for more specific and efficacious treatments. There are no cell-based models for BP; neurons of affected individuals are not accessible for study. The aims of this project are to develop, expand, and characterize cellular models of BP disorder. Induced pluripotent stem cell (iPSC) lines have been developed by reprogramming fibroblasts obtained from individuals enrolled in the Prechter longitudinal study of BP disorder. Cellular phenotypes include neural differentiation capacity, ability to form axons and branching dendrites, synapses and action potentials. Gene expression analysis and pathway analyses from 41 lines derived from 5 individuals show differences in cells derived from Bipolar and control subjects. Collaborative characterization of iPSC lines of multiple sources is sought.