Novel antibiotics are urgently needed to overcome the increasing drug-resistant bacterial infections. The main goal of this project is to design and develop cost-effective, robust, and potent “polymer antibiotics” that are effective in killing multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). These “polymer antibiotics” will be designed and synthesized by mimicking natural antibiotic peptides found in the innate immune system using advanced synthetic approaches. Our “polymer antibiotics” can be used directly in solution or attached onto medical devices and implants to treat and prevent bacterial infections. Function of these “polymer antibiotics” will be investigated using state-of-the-art spectroscopic methods. Functional insights will be further used to rationally engineer peptide-mimetic antimicrobial polymers to achieve the best activity and selectivity.
Presented at the Department of Chemistry, University of California, Irvine, CA.
Presented at IBM Research-Almaden, San Jose, CA.
Presented at the Cardiovascular Research Institute, University of California, San Francisco, CA.
Presented at the Department of Chemical Engineering, University of Washington, Seattle, WA.
Presented at the Departments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, October 13, 2017.
Decoupling the functional roles of cationic and hydrophobic groups in the antimicrobial and hemolytic activities of methacrylate random copolymers
Published article in Biomacromolecules.