Candida albicans is commonly found on healthy human hosts, in a variety of niches, including the oral mucosa, the GI tract, the vaginal mucosa, and on skin surfaces. During immunocompromisation or alterations in the host microbiome, it can cause disease in the mouth or vaginal tract. Additionally, C. albicans can cause life-threatening systemic infections when it accesses the bloodstream. The majority of the work on C. albicans has been on strains obtained from these relatively rare bloodstream infections and from oral thrush cases. The strain diversity and genotypic and phenotypic features of C. albicans from different host sites and host health statuses has not been fully explored. This project will gain insight into the relationship between commensal and pathogenic strains, and the underlying phenotypic differences that can drive disease.