A novel delivery system for cell-based therapy
Cell-based therapy represents a highly promising approach to the treatment of organ disease. Despite advances in cell delivery strategies, one key challenge is the retention and integration of cells in injured organs. Therefore, a more efficient cell delivery strategy to increase cell retention is needed. We hypothesize that a dual-delivery system to simultaneously deliver cells and sealant that prevents the leakage will improve the stem cell retention for organ regeneration.
The project aims are twofold: 1) designing and prototyping a custom syringe that can, in a single plunging action, inject stem cells and reliably seal the needle puncture with sealant in order to prevent the leakage, and 2) testing the effectiveness of the sealed stem cell injection on injured animal hearts through laboratory experiments.