Environmental stability of polyomaviruses and the impact of disulfide bridges
JC and BK polyomavirus infections are ubiquitous in humans, and the viruses are excreted at high levels in urine. The environmental fate of these viruses is therefore of interest for public health. The JC and BK capsids are composed of protein pentamers connected with inter- and intrapentameric disulfide bridges. In this project, we will explore the potential role that the capsid structure of polyomaviruses and other viruses with capsid disulfide bridges play in their environmental stability.