Evolution of Stress Neuropeptide Systems
Evolution of stress neuropeptide signaling systems
A complex physiological stress response system has evolved to ensure survival under stressful conditions. Several neuropeptide families contribute to this response, including the corticotropin-releasing factor (CRF) family of peptides, receptors and binding protein. This family appears to be conserved from honeybee to humans, with multiple evolving roles in diuresis, development/ metamorphosis, and parturition, in addition to the stress response. We propose to study neuropeptide signaling systems linked to stress, starting with the CRF peptide family, CRF receptors, and the CRF-binding protein across numerous species to address its multiples roles throughout evolution. These studies may include C. elegans, Drosophila melanogaster, Danio rerio, Xenopus laevis, Mus musculus and Homo sapiens.