Vascularizing Engineered Tissues
In vitro engineering of thick tissues is limited by the lack of perfused vasculature. Solving the vascularization problem in tissue engineering will thus represent a major step towards clinical translation of many types of engineered tissues. We have developed methods to generate rudimentary vascular networks in vitro. The purpose of this project is to optimize vascular network formation and introduce perfusion. Given the complexity of this problem, a multidisciplinary approach is required. Team expertise in vascular biology, stem cell biology, engineering and imaging would significantly enhance the success of this project.
Harnessing the Vasculogenic Properties of Mural Cells to Create Perfuseable, Complex Vascular Networks In Vitro
Presented at the TERMIS Annual Meeting 2017, Charlotte, NC