Metal Nanoshell Heating
Synthesis of gold/silver core–shell nanostructures by in situ generation of metal seeds on functionalized silica core surfaces eliminates the need for presynthesized metal seeds and a subsequent aging step. Core–shell nanoparticles with a dielectric silica core and a thin metal shell have unique photo-physical properties which can be tuned from ultraviolet–visible to near-infrared range by changing the ratio of core diameter to shell thickness.Due to their unique ability to absorb and disperse NIR radiation, metal nanoshells have found application towards cancer remediation. Fabrication of these types of nanostructures, capable of absorbing lectromagnetic radiation in a narrow range of 700–900 nm, is particularly important for such applications. It is possible to locally heat cancer tissues and destroy them by using appropriate electromagnetic radiation in combination with specific core–shell nanoparticles.
A gain of function paradox:Targeted therapy for glioblastoma associated with abnormal NHE9 expression
Glioblastoma (GBM) is the most frequent and inevitably lethal primary brain cancer in adults. It is recognized that the overexpression of the endosomal Na+/H+ exchanger NHE9 is a potent driver of GBM progression. Patients with NHE9 overexpression...
Presented at the 254th American Chemical Society National Meeting & Exposition.
Application of gold-silica core-shell nanostructures to treat gliobastoma associated with NHE9 overexpression
Glioblastoma multiformae (GBM) is the most aggressive type of malignant brain tumor with complex molecular profile. In subsets of GBM, increased expression of Na+/H+ exchanger, NHE9, is a potent driver of tumor progression and is associated with...