High Resolution Calorimetry
Elucidating the physiological and molecular mechanisms involved in metabolic regulation is critical for the treatment and prevention of cancers and other diseases such as obesity and diabetes. In fact, accumulating evidence suggests that metabolism and cancer are intricately linked, as signaling pathways that drive oncogenesis can trigger alterations in metabolic activity and mutations in certain metabolic enzymes can prime cells for malignancy. Thus, direct metabolic measurements are critically important for new insights. However, tools capable of the desired measurements with the necessary sub-nanowatt resolution do not exist. In this cube, we seek to develop ultra-sensitive calorimeters for quantifying the metabolic activity of model organisms. In conjunction with established molecular and neurobiological techniques we propose to investigate the circadian regulation of metabolism in Drosophila and neural control of metabolism in C. elegans in response to environmental cues.
$317,786 grant from the National Science Foundation.
Published in Nature (2018)
Published in Scientific Reports