Identification and characterization of cancer-associated non-coding RNAs
Cancer is to a large extent a disease of aberrant transcription. Over-expression of oncogenes and reduced expression of tumor suppressor genes are selected for during carcinogenesis. In addition, aberrantly expressed non-coding RNAs (ncRNAs) contribute to cancer by regulating protein-coding genes, chromatin structure, protein-protein interactions and acting as miRNA sponges. However, ncRNAs are poorly annotated and characterized making it difficult to link them to cancer. In this Mcubed project we will identify and characterize ncRNAs that are associated with the cancer phenotype in three different model systems. The long-term goal of this project would be to target these cancer-associated ncRNAs for cancer therapeutics.
Epigenetic Reprograming in Mutant IDH1 Low Grade Glioma Enhances Genome Stability via ATM pathway upregulation and increases Resistance to DNA Damaging Therapies
Published in Science Translational Medicine