Integration of cell growth and movement
Cell growth and movement are essential for organ development, healing of injuries and cancer progression. The critical mechanism that integrates cell growth and movement is poorly understood. This knowledge is required in order to develop targeted therapies that facilitate healing in chronic wounds or prevent cancer progression. The goal of the proposed work is to understand how rap1 integrates critical signaling pathways induced by multiple receptors. This research is significant because it is expected to reveal mechanisms that can be targeted to inhibit or promote changes required for cell movement. The long term goal is to develop mechanism-based strategies for tissue regeneration or inhibition of tumor growth.