Integration of Airborne Particle Molecular Structure & Physicochemical Properties with Exposure-Induced Toxicological Responses
Particulate matter less than 2.5 µm in diameter (PM2.5) is associated with a broad range of adverse health effects, such as cardiopulmonary disease and lung cancer. Characterization of PM2.5 molecular structure and physicochemical properties combined with investigation of physiological alterations induced by inhalation exposure are crucial to understanding the source-exposure-health effects continuum. This project will employ state-of-the art analytical techniques in support of in vitro toxicogenomic and epigenetic studies to investigate cellular responses to PM2.5 and its components. Results of the in vitro assays will serve as the basis for translating the findings into future in vivo or clinical studies. Findings will provide a link between specific sources and associated health effects by improving the understanding of molecular mechanisms. The ultimate goal is to use the detailed mechanistic understanding of the atmospheric PM effects to mitigate impacts on public health.
Bouncier Particles at Night: Composition and Temperature Drive Diel Variations in the Phase State of Atmospheric Aerosol in a Mixed Forest
Presented at the International Aerosol Conference in St. Louis, MO.