An interdisciplinary approach to understanding the inner workings of bacteria cells
In our daily lives, we encounter both beneficial and pathogenic bacteria, and these interactions shape our health and our environment. A mechanistic understanding of essential processes within bacteria, such as nutrient uptake and DNA replication, will facilitate the development of therapies to manipulate our interactions with bacteria in order to improve health and treat disease. Increasingly, new biological, biophysical and biochemical methods are uncovering with increasing detail the complexity that leads to function inside live bacterial cells. Here, by teaming up researchers across three different departments, we will take an interdisciplinary approach that incorporates molecular genetics, structural biology and super-resolution imaging in order to define how molecules work together inside bacteria cells to define the molecular interactions essential to bacterial cell biology.
Addressing the Requirements of High Sensitivity Single-Molecule Imaging of Low-Copy Number Proteins in Bacteria
Published in ChemPhysChem
$50,000 grant from the Association for Research in Otolaryngology
$186,737 grant from the NIH:Department of Health & Human Services
$1,654,079 grant from the National Institutes of Health