Currently, there is a distinct, vacant niche regarding the production of vascularized flaps. Critical-sized defects in complex reconstructive environments, such as the mandible, have been ameliorated in certain patient populations in the past utilizing techniques such as free fibula or iliac bone grafts. By manufacturing custom bone borne free flaps in a vascularized autologous bio-reactor environment, we aim to circumvent the issues afflicting the current reconstructive stratagem, such as the significant time and effort to cut and shape the bony free flap to fit the defect, scarce donor sites, as well as donor site morbidity.
We are aiming to further design a bio-reactor that a) releases necessary growth factors to achieve this goal; b) allows us to visualize the development, progress, and incubation of the flap, and; c) is of a geometry that minimizes the possibility of extrusion of the bio-reactor or other damage to the host enviornment.
Radiolucent Molds Design and Stereolithography Fabrication for In-Vivo Tissue Transformation to Vascularized Bone Grafts
Published in Rapid Prototyping
3D-Printed Porous Structure and Polymer Infiltration for Fabrication of Functionally Gradient Material with Complex Shape
$90,277 Texas A&M/NSF CMMI grant