MicroRNA regulation in adrenocortical disease
Three investigators across the UMMS and LSI will examine the MicroRNA signature in benign and malignant adrenal tumors.
Tom Giordano is a recognized exoert in adrenal pathology
Gary Hammer idirects the Adrenal Cancer Program at Um
John Kim is a leader in the field of miRNA biology
This is a completely new direction for these 3 labs. It is risky because it is hypothesis GENERATING. It is interdisciplinary as it requires the expertese of a clinical scientist (Hammer), molecuarl pathologist( Giordano) and basic scientist (Kim). miRNAs have been shown to be critical for both developmental processes and cancer in a variety of organs. We anticipate this project to lead to new understanding of the molecular control of gene expression as it pertains to the malignant transformation of adrenocortical cells. Ideally, insights will be made that have import for new therapies for this fatal disease,