Obesity and type II diabetes have enormous impact on health and health care costs. Bariatric surgery remains the single most effective option to cause weight loss and diabetes resolution. However, these are invasive procedures and cannot be scaled to deal with the millions of affected individuals. The mechanisms behind these potent improvements are not because these procedures make the stomach smaller but rather they change the communication between the GI tract and other metabolic organs including the brain. The key insight driving this proposal is that some of these effects are the result of efferent or afferent signal changes in the nerves of the visceral organs. The goal of this proposal is to use targeted stimulation of peripheral nerves to mimic critical effects of these surgeries and thereby provide novel therapeutic strategies that can help far more people than can be reached by the present procedures.
Kilohertz frequency stimulation of renal nerves for modulating blood glucose concentration and urine glucose excretion in a diabetic rat model.
This poster presentation presented data on bilateral kidney stimulation in diabetic-model rats.
This poster presentation summarized our experiments using electrical stimulation on one kidney.
This poster presented preliminary data on modulating kidney function with electrical stimulation.
In this paper we demonstrated that electrical stimulation of renal nerves can modulate the kidney's control over glucose filtration.