Understanding the impact of shock waves on tumor cells
The goal is to develop a novel non-intrusive targeted tumor therapy using micro-shock waves. A shock wave is a high intensity wave that causes a rapid pressure increase, which leads to a density change in a fluid. When the shock wave travels through the fluid medium and impacts the mixed solid-fluid media in the body, pressure waves will be generated, which will in turn affect cell permeability, vascular structure, and development. We propose to develop a micro-shock wave generation technique for targeted tumor therapy by transiently increasing the permeability of the epidermal layer, and delivering drugs targeted to tumor cells. The benefits include localized, controlled, and rapid treatment that can mitigate the need for chemotherapy. We will perform numerical and in vitro experimental modeling to understand shock wave propagation through mixed fluid-solid media and impact on tumor cells, and conduct in vivo experimental modeling of sum 149 breast cancer cells in mice.
Presentation to Naval Architecture and Marine Engineering