Research utilizing event-related brain potentials (ERPs) suggest that reduced P300 amplitude and prolonged latency may qualify as a biomarker for schizophrenia (SZ). In two studies, we examined P300 characteristics during a response inhibition among four groups including schizophrenia (SZ), bipolar I disorder (BD), schizoaffective disorder (SA) and healthy controls (CT). In both studies, six selected P300 variables correctly classified SZ (79%), SA (55%) and CT (87%) (study 1), and SZ (59%), BD (74%) and CT (60%) (study 2). The findings suggest that distinct P300 features in response inhibition tasks may be biomarkers with the capacity to distinguish BD, CT and SZ. The goal of this current project is to take our previously established results and apply to new populations to determine the validity of our measures and ultimately to determine the viability of P300 as a biomarker of schizophrenia.
Published article in Scientific Reports.