GABAergic interneurons may an essential role in cortical microcircuitry, part of a finely tuned mechanism maintaining excitatory-inhibitory balance in the cortex. Disruptions of this system have been identified in post-mortem studies of schizoprenia patients (reductions in the GAD67 enzyme which synthesizes GABA), and reduction in GABA has been associated with aging and a reduced ability of circuitry to process distinctive stimulus inputs. There is an important need for probes of GABAergic functions in humans. Paired pulse stimulation with transcranial magnetic stimulation (ppTMS) applied to the motor cortex at specific intervals (short interval intra-cortical inhibition, 1-4 msec) is probe of GABAergic function in the motor cortex. This project will seek to develop this probe in the occipital cortex, using phosphene generation as a dependent measure, expanding the tool to examine GABAergic function in disease and healthy aging.
Presented at the 2018 Society for Neuroscience; San Diego, CA.
Presented at the 2017 Society for Neuroscience; Washington, DC.
Presented at the 2017 MCubed Symposium; Ann Arbor, MI.
Given at the Presentation at the annual meeting of the Society for Neuroscience, Washington, DC, November 2017.
Probing short-interval cortical inhibition in the visual cortex with transcranial magnetic stimulation: A reliability study
Published article in Brain Stimulation.
Presented to the Society for Neuroscience