The understanding of interaction mechanisms between cancer cells and the tumor microenvironment (TME) is crucial for developing therapies that can arrest tumor progression and metastasis. Cancer associated fibroblasts (CAFs) are the major constituent of the TME in many cancers and have been found to positively regulate tumor growth and metastasis through intercellular communications with cancer cells. Still little is known about their role in inducing metabolic reprogramming in cancer cells. Exosomes carry information from one cell to another and reprogram the recipient cells, and recent findings report that exosomes harbor the potential to regulate proliferation of recipient cells. Although it has been shown that CAFs can induce metabolic reprogramming in cancer cells, the contribution of CAF-derived exosomes has not been elucidated. We intend to elucidate the role of TME in regulating metabolic enzymes involved in heterochromatin regulation within cancer cells.