Ph.D., 2000, Pennsylvania State University College of Medicine
Post-doctoral research in the Department of Orthopaedic Surgery at Penn State and then at Duke University.
Post-doctoral fellowship through the Regenerative Sciences Training Program at the University of Michigan.
2006 Joined Department of Orthopaedic Surgery
Her research program focuses on identifying contributions of the bone tissue microenvironment-particularly the extracellular matrix- to bone cellular physiology in the contexts of development and regeneration.
Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastucture and leads to a brittle bone phenotype. Manley E Jr, Perosky JE, Khoury BM, Reddy AB, Kozloff KM, Alford AI. J Appl Physiol. 2015 Aug 13:jap.00340.2015. doi: 10.1152/japplphysiol.00340.2015 [Epub ahead of print]. PMID: 26272319
Extracellular matrix networks in bone remodeling. Alford AI, Kozloff KM and Hankenson KD. Int J Biochem Cell Biol. 2015 65:20-31 (Review). PMID: 25997875
Thrombospondin-2 facilitates assembly of a type-I collagen-rich matrix in marrow stromal cells undergoing osteoblastic differentiation. Alford AI, Golicz AZ, Cathey AL, Reddy AB. Connect Tissue Res. 2013;54(4-5):275-82. doi: 10.3109/03008207.2013.811236. Epub 2013 Jul 19. PMID: 23763373 [PubMed - indexed for MEDLINE]
Two molecular weight species of thrombospondin-2 are present in bone and differentially modulated in fractured and nonfractured tibiae in a murine model of bone healing. Alford AI, Reddy AB, Goldstein SA, Murthy P, Tayim R, Sharma G. Calcif Tissue Int. 2012 May;90(5):420-8. doi: 10.1007/s00223-012-9580-y. Epub 2012 Feb 24. PMID: 22362307 [PubMed - indexed for MEDLINE] Free PMC Article