Research in the Liu lab lies at the interface of biology and engineering. We are fascinated by cellular dynamics and mechanics, particularly during cell migration and clathrin-mediated endocytosis. The theme of biological signal processing at the membrane will be explored using both top-down and bottom-up approaches.
H. Lin, A.P. Liu, T.H. Smith, J. Trejo, “Dimerization and cofactoring between proteinase-activated receptors: implications for ligand and signaling specificity”, Pharmacological Reviews, submitted.
D. Nunez, C. Antonescu, M. Mettlen, A,P. Liu, S.L. Schmid, D. Loerke, G. Danuser, “Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources”, Traffic, vol 12 (12), 1868-78, 2011.
A.P. Liu, F. Aguet, G. Danuser, S.L. Schmid, “Local clustering of transferrin receptors promotes clathrin-coated pit initiation”, Journal of Cell Biology, vol 191 (7), 1381-1393, 2010.
D. Banerjee, A.P. Liu, N. Voss, S.L. Schmid, M.G. Finn, “Multivalent display of transferrin on virus-like particles by click chemistry and receptor-mediated endocytosis”, ChemBioChem, vol 11, 1273-1279, 2010.
A.P. Liu, D. Loerke, S.L. Schmid, G. Danuser, “Global and local regulation of clathrin coated pit dynamics detected on patterned substrates”, Biophysical Journal, vol 97 (4), 1038-1047, 2009.
A.P. Liu, D.A. Fletcher, “Biology under construction: in vitro reconstitution of cellular processes”, Nature Reviews Molecular Cell Biology, vol 10 (9), 644-650, 2009.