Research in the Allen Lab is broadly focused on understanding the mechanisms of growth factor and morphogen signaling in development and disease. Specifically, we study the regulation of Hedgehog (HH) signaling during vertebrate embryogenesis using a wide range of approaches, including mouse developmental genetics, chick in ovo electroporation, biochemistry, and cell biology. The long-term goal of our research is to use insights gained from the study of HH signaling in normal development in the treatment of a broad spectrum of developmental diseases and childhood and adult cancers.
Zhang, H., Kamiya, N., Tsuji, T., Takeda, H., Scott, G., Rajderkar, S., Ray, M.K., Mochida, Y., Allen, B., Lefebvre, V., Hiung, I.H., Ornitz, D.M., Kunieda, T., and Mishina, Y., Elevated Fibroblast Growth Factor Signaling is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice, PLoS Genetics, 2016, Dec 27; 12(12):e1006510. doi: 10.1371/journal.pgen.1006510. eCollection 2016. PMID: 28027321.
Ermilov, A.N.*, Kumari, A.*, Li, L., Joiner, A.M., Grachtchouk, M.A., Allen, B.L., Dlugosz, A.A., and Mistretta, C.M., Maintenance of Taste Organs is Strictly Dependent on Epithelial Hedgehog/GLI Signaling, PLoS Genetics, 2016, Nov 28; 12(11):e1006442. doi: 10.1371/journal.pgen.1006442. eCollection 2016. PMCID: PMC5125561.
Lorberbaum, D.S.*, Ramos, A.I.*, Peterson, K.A., Carpenter, B.S., De, S., Parker, D.S., Chiang, A.C.Y, Kassis, J.A., Allen, B.L., McMahon, A.P., and Barolo, S., An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/PTCH1, eLife, 2016, May 5 PMCID: PMC4887206.
Allen, B.L., Spinal Cords Built to Scale, Developmental Cell, 2016, Apr 18; 37(2): 108-109; doi: 10.1016/j.devcel.2016.04.007. PMID: 27093078.
Coffman, L.G., Choi, Y., Mclean, K., Allen, B.L., Pasca di Magliano, M., and Buckanovich, R.J., Human Carcinoma-Associated Mesenchymal Stem Cells Promote Ovarian Cancer Chemotherapy Resistance via a BMP4/HH signaling loop, Oncotarget, 2016, Feb 9; 7(6): 6916-6932. PMCID: PMC4872758.