Associate Director, CSCAR
Brenda Gillespie is a Research Associate Professor of Biostatistics and Associate Director of UM's Center for Statistical Consultation and Research (CSCAR). She provides statistical collaboration and support for numerous research projects at the University of Michigan. She teaches Biostatistics courses as well as CSCAR short courses in survival analysis, regression analysis, sample size calculation, generalized linear models, meta-analysis, and statistical ethics. Her major areas of expertise are clinical trials and survival analysis.
My research interests are in the area of censored data and clinical trials. One research interest concerns the application of categorical regression models to the case of censored survival data. This technique is useful in modeling the hazard function (instead of treating it as a nuisance parameter, as in Cox proportional hazards regression), or in the situation where time-related interactions (i.e., non-proportional hazards) are present. Another area of interest is the analysis of cross-over trials with censored data. I have developed (with M. Feingold) a set of nonparametric methods for testing and estimation in this setting. Our methods out-perform previous methods in most cases. A third area of interest is the left-censored data setting, particularly as applied to data below a limit of detection. I have a recent paper on use of the reverse Kaplan-Meier estimator in this setting. Another paper on estimation of the correlation coefficient in the presence of left-censored data is in progress. I also collaborate and publish extensively with several investigators in various areas of health research.
Trotter JF, Gillespie BW, Terrault NA, Abecassis MM, Merion RM, Brown RS Jr, Olthoff KM, Hayashi PH, Berg CL, Fisher RA, Everhart JE; Adult-to-Adult Living Donor Liver Transplantation Cohort Study Group. Laboratory test results after living liver donation in the adult-to-adult living donor liver transplantation cohort study. Liver Transpl. 2011 Apr;17(4): 409-17. doi: 10.1002/lt.22246. PMID:21445924
Gillespie BW, Merion RM, Ortiz-Rios E, Tong L, Shaked A, Brown RS, Ojo AO, Hayashi PH, Berg CL, Abecassis MM, Ashworth AS, Friese CE, Hong JC, Trotter JF, Everhart JE and the A2ALL Study Group. Database comparison of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) and the SRTR U.S. transplant registry. Am J Transplant. 2010; 10(7):1621-1633. PMID: 20199501.
Gillespie BW, Chen Q, Reichert H, Franzblau A, Hedgeman E, Lepkowski J, Adriaens P, Demond A, Luksemburg W and Garabrant D. Estimating population distributions when some data are below a limit of detection using a reverse Kaplan-Meier estimator. Epidemiology 2010; 21:Suppl 4:S64-70. PMID: 20386104.
Kumar B, Tilea A, Gillespie BW, Zhang X, Kiser M, Eisele G, Finkelstein F, Kotanko P, Levin N, Rajagopalan S, Saran R. Significance of self-reported sleep quality (SQ) in chronic kidney disease (CKD): the Renal Research Institute (RRI)-CKD study. Clin Nephrol. 2010 Feb;73(2):104-14. PubMed PMID: 20129017.
Sengstock D, Sands RL, Gillespie BW, Zhang X, Kiser M, Eisele G, Vaitkevicius P, Kuhlmann M, Levin NW, Hinderliter A, Rajagopalan S, Saran R. Dominance of traditional cardiovascular risk factors over renal function in predicting arterial stiffness in subjects with chronic kidney disease. Nephrol Dial Transplant. 2010 Mar;25(3):853-61. Epub 2009 Oct 23. PubMed PMID: 19854848.
Sen A, Lee SY, Gillespie BW, Kazerooni EA, Goodsitt MM, Rosenman KD, Lockey JE, Meyer CA, Petsonk EL, Wang ML, Franzblau A. Comparing film and digital radiographs for reliability of pneumoconiosis classifications: a modeling approach. Acad Radiol. 2010 Apr;17(4):511-9. PMID: 20207319.
Bard RL, Gillespie BW, Lange DC, Nicklas JM. Improving prognostic assessment of patients with advanced heart failure using ventilatory efficiency. J Heart Lung Transplant. 2010 May;29(5):589-91. Epub 2009 Dec 22. PMID: 20022770.
Janz NK, Musch DC, Gillespie BW, Wren PA, Niziol LM; Collaborative Initial Glaucoma Treatment Study (CIGTS) Investigators. Evaluating clinical change and visual function concerns in drivers and nondrivers with glaucoma. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1718-25. PMID: 19060263
Zick SM, Vautaw BM, Gillespie B, Aaronson KD. Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. Eur J Heart Fail. 2009 Oct;11(10):990-9.PMID: 19789403
Garabrant DH, Franzblau A, Lepkowski J, Gillespie BW, Adriaens P, Demond A, Hedgeman E, Knutson K, Zwica L, Olson K, Towey T, Chen Q, Hong B, Chang CW, Lee SY, Ward B, Ladronka K, Luksemburg W, Maier M. The University of Michigan Dioxin Exposure Study: predictors of human serum dioxin concentrations in Midland and Saginaw, Michigan. Environ Health Perspect. 2009 May;117(5):818-24. PMID: 19479027