My research is primarily focused on mechanisms of circadian rhythms assayed by melatonin output from the pineal gland. More recently, we have begun investigation of mechanisms of functional recovery from nerve injury in adult mammals using the SCG (superior cervical ganglion)-pineal neurocircuit as a model system. In addition, we are exploring various neurochemicals secreted from the pineal gland and the surrounding brain tissues to gain a comprehensive understanding of brain neurochemistry under various physiological states.
Circadian regulation of pineal gland rhythmicity. Borjigin J, Zhang LS, Calinescu AA. Mol Cell Endocrinol. 2012 Feb 5;349(1):13-9. Epub 2011 Jul 18. Review. PMID: 21782887
Transsynaptic activity-dependent regulation of axon branching and neurotrophin expression in vivo. Calinescu AA, Liu T, Wang MM, Borjigin J. J Neurosci. 2011 Sep 7;31(36):12708-15. PMID: 21900550
Ischemic stroke selectively inhibits REM sleep of rats. Ahmed S, Meng H, Liu T, Sutton BC, Opp MR, Borjigin J, Wang MM. Exp Neurol. 2011 Dec;232(2):168-75. Epub 2011 Aug 30. PMID: 21906592
N-terminal residues regulate proteasomal degradation of AANAT. Huang Z, Liu T, Borjigin J. J Pineal Res. 2010 Apr;48(3):290-6. Epub 2010 Mar 4. PMID: 20210853
Dissociation of circadian and light inhibition of melatonin release through forced desynchronization in the rat. Schwartz MD, Wotus C, Liu T, Friesen WO, Borjigin J, Oda GA, de la Iglesia HO. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17540-5. Epub 2009 Sep 30. PMID: 19805128