Carlos Aguilar is an assistant professor at the University of Michigan College of Engineering and is the head investigator at the NOBEL Lab. Aguilar completed his PhD in BME at the University of Texas at Austin then joined MIT Lincoln Laboratory’s Bioengineering Systems and Technology Group. Working with Harvard, the Broad Institute, and the U.S. Army Institutes of Surgical Research and Environmental Medicine, Aguilar developed programs using sequencing-based tools to investigate the molecular mechanisms regulating muscle healing after trauma.
The main research thrusts of Professor Aguilar's laboratory are in 1) muscle stem cell biology and muscle regeneration (myogenic lineage progression, cellular communication networks, adaptation to stimuli), 2) cellular reprogramming and cell-fate plasticity (transcriptional and epigenetic factors, microenvironment interactions, chromatin memory), 3) regenerative medicine (rehabilitation, cell-based therapies and artificial scaffolds) and 4) micro/nanodevices for interacting with and manipulating single cells and molecules. To study these areas, we interact with clinicians and translational scientists to develop and utilize tools such as integrative genomic assays and high-throughput sequencing, micro/nanofabricated devices, genome editing and computational modeling.
Carlos A. Aguilar, Anna Shcherbina, Darrell O. Ricke, Ramona Pop, Christopher T. Carrigan, Casey A. Gifford, Maria L. Urso, Melissa A. Kottke, Alexander Meissner. “In vivo Monitoring of Transcriptional Dynamics After Lower-Limb Muscle Injury Enables Quantitative Classification of Healing”. Scientific Reports. 5:13885 (2015).
Carlos A. Aguilar, Ramona Pop, Anna Shcherbina, Alain Watts, Ronald W. Matheny Jr., Davide Cacchiarelli,Woojin M. Han, Eunjung Shin, Shadi A. Nakhai, Young C. Jang, Christopher T. Carrigan, Casey A. Gifford, Melissa A. Kottke, Marcella Cesana, Maria L. Urso, Alexander Meissner. “Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma.” Stem Cell Reports, Volume 7, Issue 5, Pages 983–997 (2016).
Ronald W. Matheny Jr., Christopher T. Carrigan, Mary N. Abdalla, Alyssa V. Geddis, Luis A. Leandry, Carlos A. Aguilar, Stuart S. Hobbs, Maria L. Urso. “RNA transcript expression of IGF-1:PI3K pathway components in regenerating skeletal muscle is sensitive to initial injury intensity”. Growth Hormone & IGF Research, Vol. 32, Pages 14-21 (2017).
Sarah M. Greising, Jessica C. Rivera, Stephen M. Goldman, Alain Watts, Carlos A. Aguilar, Benjamin T. Corona. “Unwavering pathobiology of volumetric muscle loss injury”. Scientific Reports. 7: 13179 (2017).
Carlos A. Aguilar, Sarah M. Greising, Alain Watts, Stephen M. Goldman, Chelsea Peragallo, Christina Zook, Jacqueline Larouche, Benjamin T. Corona. “Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury”. Cell Death Discovery, 4: 33 (2018).