Dr. Carey received his B.S. from Saint Lawrence University in Canton, N.Y. He earned his Ph.D. in Biochemical Pharmacology from State University of New York at Buffalo, and completed a postdoctoral fellowship focusing on melanoma immunology and serology at Sloan-Kettering Institute, New York, N.Y. in 1977. After active duty for training in the Army Medical Service Corps from 1977-1978, he joined the University of Michigan Medical School faculty in 1978 where he has spent the majority of his career rising through the ranks to Full Professor, developing and leading the University of Michigan Head and Neck Cancer research program. He served a 5 year term as the Chair of the Department of Oral Medicine, Pathology and Oncology in the School of Dentistry where he held the Donald A. Kerr Collegiate Professorship in Oral Pathology/Oncology. He is the Director of two laboratories, the Head and Neck Cancer Biology Laboratory in the Cancer Center and the Cell Biology and Immunology Laboratory in the Kresge Hearing Research Institute. Dr. Carey has authored or co-authored over 185 peer reviewed articles, over 380 abstracts, 20 book chapters, and one book. Dr. Carey has served on the NIH NIDCD AUD study section and the US Army Prostate Cancer Research Program Integration Panel as well as numerous review panels and advisory committees for the NCI and NIDCR. Dr Carey also serves as a member of numerous External Advisory Boards at other institutions.
My interests are linked to the current epidemic of high risk HPV induced head and neck cancer. IN 2013 the incidence of invasive oropharyngeal cancer in the United States is expected to exceed the incidence of invasive cervical cancer by rising to more than 13,000 cases. At the unniversity of Michigan our studies have shown a consist rise in the proportion of HPV positive oropharynx cancers over the past decade such that more than 90% of these tumors contain high risk HPV. The incidence of HPV induced cancer of the uterine cervix is falling because of early detection and treatment of preinvasive disease, but there is no analogous early detection for early cancer of the oropharynx. Additionally, our studies have shown that high risk HPV is also present in 50% of nasopharyngeal cancers seen at U of M and 8-10 percent of oral and laryngeal cancers. Patients and their spouse or partners are concerned about risk of transmission of an oncogenic virus. To better understand the relationship between oral HPV infection, head and neck cancer and early detection we have initiated studies of oral rinses to detect HPV and to examine its status vis a vis infectious virus, integrated virus, or latent virus and whether the virus is likely to be associated with an oncogenic process. To accomplish this we propose to team up with epidemiology, gynecology and head and neck colleagues to study the history of oral infection in women with cervical infections, men and women with oral infections and patients with cancer to elucidate this question.
Tang AL, Davis SJ, Owen JH, Graham MP, Czerwinski MJ, Park JJ, Walline H, Stoerker J, McHugh JB, Chepeha D, Bradford CR, Carey TE, Prince ME. UM-SCC-104: a new human papillomavirus-16 containing head and neck squamous cell carcinoma cell line. Head Neck 2011 Dec 13. doi: 10.1002/hed.21962. [Epub ahead of print] (PMCID: PMC3369005)
Sartor MA, Dolinoy DC, Jones TR, Colacino JA, Prince MEP, Carey TE, Rozek LS. Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis. Epigenetics 6(6): 777-787, 2011. (PMCID: PMC3142368)
Maxwell JH, Kumar B, Feng FY, Worden FP, Lee, J, Eisbruch, A, Wolf, GT, Prince, ME, Moyer, JS, Teknos TN, Chepeha DB, McHugh JB, Urba, S, Stoerker J, Walline H, Kurnit, D, Cordell KG, Davis, S, Ward, PD, Bradford CR, Carey TE. Tobacco use in HPV-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res 16:1226-1235, 2010. (PMCID: PMC2822887)
Maxwell JH, Kumar B, Feng FY, McHugh JB, Cordell KG, Eisbruch A,; Worden FP, Wolf GT, Prince ME, Moyer JS, Teknos TN, Chepeha DB, Stoerker J, Walline H, Carey TE, Bradford CR. HPV-Positive/p16-Positive/EBV-Negative Nasopharyngeal Carcinoma in White North Americans. Head and Neck 32:562-567, 2010. (PMCID: PMC2855405)
Worden FP, Kumar B, Lee JS, Wolf GT, Cordell KG, Taylor JMG, Urba SG, Eisbruch A, Teknos TN, Chepeha DB, Prince ME, Tsien CI, D‰ÛªSilva NJ, Yang K, Kurnit DM, Mason HL, Miller TH, Wallace NE, Bradford CR, Carey TE. Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: Response and survival positively associated with HPV16 copy number. J Clin Oncol 26:3138-3146, 2008. (PMCID: PMC2742158)