Dr. Duan received his B.S. degree from the Ocean University of China and his Ph.D. degree from the University of Tokyo. He was a postdoctoral research associate at the University of Washington and a postdoctoral fellow at the University of North Carolina at Chapel Hill.
Research in the Duan lab is directed towards understanding how peptide growth factors act to regulate cell proliferation, differentiation, migration and apoptosis in response to hypoxia and nutrient restriction. Our current research focuses on the insulin-like growth factor (IGF) signaling system and hypoxia inducible factors (HIFs). The Duan lab uses zebrafish, mammalian cells, and other animals as experimental models. Specific areas of current research activity include: (1) roles of growth factors in regulating cell proliferation, differentiation, migration and apoptosis; (2) signal transduction mechanisms of growth factor actions; (3) transcriptional and post-transcriptional regulation of gene expression by hypoxia; and (4) roles of growth factors and HIFs in regulating development, growth, and aging in response to hypoxia and nutrient restriction.
Fukushima, T., Yoshihara, H., Furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S-I., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., and Takahashi, S-I. (2015) Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity. Nature Commun. 16:6:6780.
Dai, W., Bai, Y., Zhong, X., Hebda, L., Liu, J., Kao, J., and Duan, C. (2014) Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial proliferation. Cell Death and Differ. 21:568-581.
Zhang, P., Yao, Q., Lu, L., Li, Y. and Duan, C. (2014) Hypoxia inducible factor-3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 6: 1110-1121.
Huang, Y., Harrison, M., Osorio, A., Kim, J., Baugh, A., Duan, C., Sucov, H., and Lien, C.-I. (2013) IGF signaling is required for cardiomyocyte proliferation during zebrafish heart development and regeneration. PLoS One, 8(6):e67266.
Zhou, J., Xiang, J., Zhang, S., and Duan, C. (2013) Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions. Endocrinology, 154:3753-63.
Zhang, C., Lu, L., Li, Y., Zhou, J., Liu, Y., Fu, P., Gallicchio, M.A., Bach, L.A. and Duan, C. (2012) IGF binding protein 6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. Int. J. Cancer, 130:2003-2012.
Onuma, T.A. and Duan, C.. (2012). "Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity." FASEB J, 26: 2941-2950.
Onuma, T.A., Ding, Y., Abraham, E., Zohar, Y., Ando, H., Duan, C.. (2011). "Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish." Journal of Neuroscience 31:11814-24.
Zhong, Y., Lu, L., Zhou, J., Li,Y., Liu, Y. Clemmons, D.R. and Duan, C.. (2011). "IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP action in zebrafish embryos." Journal of Cell Science 124: 1925-1935.
Kamei, H., Ding, Y., Kajimura, S., Wells, M., Chiang, P. and Duan, C. (2011). "Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability." Development 138: 777-786.
Ren, H., Accili, D., and Duan, C.. (2010). "Hypoxia converts the myogenic action of IGFs into mitogenic action by differentially regulating multiple signaling pathways." Proc Natl Acad Sci USA. 107:5857-62.