B.S., Biology, University of Science & Technology of China (USTC)
Ph.D., Molecular Biophysics, Division of Biology and Biomedical Sciences, Washington University School of Medicine
Postdoctoral training, Carlos Bustamante Lab, University of California at Berkeley
We are interested in fundamental questions that can facilitate therapeutic development and delivery. For example, how efficient is a virus in transmitting themselves among host cells? Answers to this question can enlighten therapeutic strategies to block virion infection, and also improve vaccine and gene delivery using viruses as vectors. We realize that the ways to address these questions are often limited by our understanding of these processes at molecular and cellular level, which is one of the many reasons that we study and dissect these processes, in particular aided by novel biophysical techniques that we also develop in the lab.
- Efficiency of viral entry
- Development of single-molecule manipulation and imaging techniques
B. Koh, G. Kim, H. Yoon, J. B. Park, R. Kopelman, and W. Cheng. (2012). Fluorophore and Dye-Assisted Dispersion of Carbon Nanotubes in Aqueous Solution. Langmuir in press.
X. Hou, and W. Cheng. (2012). Detection of Single Fluorescent Proteins inside Eukaryotic Cells Using Two-photon Fluorescence. Biomed. Opt. Express 3: 340-353.
W. Cheng. (2012). Force-fluorescence spectroscopy. In: Roberts GC. Encyclopedia of Biophysics. Heidelberg, Springer; (forthcoming).
X. Hou, and W. Cheng. (2012). Optical Tweezers. In: Roberts GC. Encyclopedia of Biophysics. Heidelberg, Springer; (forthcoming).
W. Cheng, S. G. Arunajadai, J. R. Moffitt, I. Tinoco Jr., and C. Bustamante. (2011). Single Base Pair Unwinding and Asynchronous RNA Release by the HCV NS3 Helicase. Science 333: 1746-1749.
X. Hou, and W. Cheng. (2011). Single-Molecule Detection Using Continuous-Wave Excitation of Two-Photon Fluorescence. Opt. Lett. 36: 3185-3187. (Also selected for publication in the Virtual Journal for Biomedical Optics)
C. Bustamante, W. Cheng, and Y. X. Meija. (2011). Revisiting the Central Dogma One Molecule at a Time. Cell. 144: 480-497.
B. Koh, J. B. Park, X. Hou, and W. Cheng. (2011). Comparative Dispersion Studies of Single-Walled Carbon Nanotubes in Aqueous Solution. J. Phys. Chem. 115: 2627-2633.
J. Yu, W. Cheng, C. Bustamante and G. Oster. (2010). Coupling Translocation with Nucleic Acid Unwinding by NS3 Helicase. J. Mol. Biol. 404: 439-455.
W. Cheng, X. Hou, and F. Ye. (2010). Use Tapered Amplifier Diode Laser for Biological-Friendly High-Resolution Optical Trapping. Opt. Lett. 35: 2988-2990