Ph.D. University of California, Berkeley. Mechanical Engineering. 2004.
B.A. Aristotle University of Thessaloniki, Greece. Mechanical Engineering. 1998.
We are developing Micro/Nano Electroctro-Mechanical Systems (MEMS/NEMS) to address: (i) fundamental questions in neuroscience, (ii) clinical needs in the medical field.
Bio-MEMS/NEMS in NeuroScience. How do neural circuits generate behavior? How the functionality of neural circuits is alterted with age? We combine micro/nano fabrciation technology with bio-imaging approaches to study the nervous system of the nematode C.elegans in vivo.
We are also interested in developing solid-state nanoprobes for measuring membrane potential from neurons in vitro.
Bio-MENS/NEMS in Medicine. We are interested in engineering point-of-care diagnostic biochips as well as in implantable medical devices. By integrating microfluidic and microoptical components, we are developing innovative tools for monitoring infectious diseases in the developing world as well as novel biosensing approaches for monitoring traumamtic brain injuries and diseases related to high intraocular pressure.
Ghannad-Rezaie M., Yang L., Garton H. and Chronis N. A Near Infrared Opto-mechanical Intracranial Pressure Microsensor. Journal of Microelectromechanical Systems (in press).
Tripathi A. and Chronis N., A doublet microlens array for imaging micron-sized objects, J. Micromech. Microeng. Vol. 21, Number 10, doi:10.1088/0960-1317/21/10/105024 (2011).
Chokshi T.V., Bazopoulou D. and Chronis N., Probing the physiology of ASH neuron in Caenorhabditis elegans using Electric Current Stimulation, Applied Physics Letters 99, 053702 (2011).
Chokshi T.V., Bazopoulou D. and Chronis N., An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans, Lab Chip. 10(20):2758-63 (2010).
Chronis N., Worm Chips: Microtools for C. elegans Biology, Lab Chip, 2010, 10, 432 ? 437.
Ben-Yakar A., Chronis N. and Lu H., Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in worms, Current Opinion in Neurobiology, Oct;19(5):561-7 (2009).