Ph.D. Yale University. Mechanical Engineering. 1995.
M.Phil. Yale University. Mechanical Engineering. 1992.
M.S. Nanjing University, Nanjing, P.R. China. Acoustics. 1988.
B.S. Nanjing University, Nanjing, P.R. China. Physics. 1985.
Professor Deng's lab focuses on research and development in the field of biomedical ultrasound. The objective of the lab is to obtain improved understanding of the processes and mechanism involved in ultrasound interaction with biological systems for the purpose of developing efficient techniques for diagnosis and treatment of human diseases. Specific research projects include ultrasound mediated drug and gene delivery for cancer treatment and gene therapy, high intensity focus ultrasound ablation of cardiac arrhythmias such as atrial fibrillation, as well as quantitative ultrasound imaging for improved pancreatic cancer detection.
Fan Z, Liu H, Mayer M, Deng CX. Spatiotemporally controlled single cell sonoporation. Proceedings of the National Academy of Sciences of the United States of America 2012. (In press)
Gudur MSR, Kumon RE, Zhou Y, Deng CX. Multispectral analysis of ultrasound backscatter for characterization of HIFU lesions in cardiac tissue with high-frequency imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2012. (In press)
Gudur M, Rao RR, Hsiao Y, Peterson AW, Deng CX, Stegemann JP. Noninvasive, Quantitative, Spatiotemporal Characterization of Mineralization in 3D Collagen Hydrogels Using High Resolution Spectral Ultrasound Imaging. Tissue Engineering Part C Methods. 2012. (in press)
Kumon RE, Repaka A, Atkinson M, Faulx AL, Wong RCK, Isenberg GA, Hsiao Y, Gudur MSR, Deng CX, Chak A. Characterization of Pancreas In Vivo using Endoscopic Ultrasound Spectrum Analysis with Electronic-Array Echoendoscopes. Gastrointestinal Endoscopy. 2012. 75:1175-83.
Fang Y, Frampton JP, Raghavan S, Sabahi-Kaviani R, Luker G, Deng CX, Takayama S. Rapid generation of multiplexed cell co-cultures using acoustic droplet ejection followed by aqueous two-phase exclusion patterning. Tissue Engineering Part C Methods. 2012;18:647-57.
Kumon RE, Repaka A, Atkinson M, Faulx AL, Wong RCK, Isenberg GA, Hsiao Y, Gudur MSR, Deng CX, Chak A. Lymph Node Characterization In Vivo using Endoscopic Ultrasound Spectrum Analysis with Electronic-Array Echoendoscopes. Endoscopy. 2012; 44:618-21
Laughner JI, Sulkin MS, Wu Z, Deng CX, Efimov IR. Three potential mechanisms for failure of HIFU ablation in cardiac tissue. Circulation Arrhythmia and Electrophysiology. 2012;5:409-16.
Kumon RE, Gudur MSR, Zhou Y, Deng CX. High-frequency ultrasound M-mode techniques for real time monitoring of HIFU ablation. Ultrasound in Medicine and Biology 2012; 38: 626-641.
Zhou Y, Yang K, Cui J, Ye J, Deng CX. Controlled permeation of the cell membrane by single bubble acoustic cavitation. Journal of Controlled Release. 2012; 157:103-111.
Kumon RE, Deng CX, Wang X. Frequency-domain analysis of photoacoustic imaging data from prostate adenocarcinoma tumors in a murine model. Ultrasound in Medicine and Biology 2011. 37:834-839.
Park J, Fan Z, Deng CX. Effects of shear stress cultivation on cell membrane disruption and intracellular calcium concentration in sonoporation of endothelial cells. Journal of Biomechanics 2011. 44:164-169.
Grainger SJ, Serna JV, Sunny S, Zhou Y, Deng CX, El-Sayed MEH. Pulsed ultrasound enhances nanoparticle penetration into breast cancer spheroids. Molecular Pharmaceutics 2010; 7:2006-2019.
Zhang JF, Villacorta L, Chang L, Fan ZZ, Hamblin M, Zhu TQ, Chen CS, Cole MP, Schopfer FJ, Deng CX, Garcia-Barrio MT, Feng YH, Freeman BA, Chen YE. Nitro-oleic acid inhibits angiotensin II-induced hypertension. Circulation Research 2010. 107: 540-U200.
Park J, Fan Z, Kumon RE, El-Sayed ME, Deng CX. Modulation of intracellular calcium concentration in brain microvacular endothelia cells in vitro by acoustic cavitation. Ultrasound in Medicine and Biology 2010; 36:1176-1187.
Fan Z, Kumon RE, Park J, Deng CX. Intracellular delivery and calcium transients generated in sonoporation facilitated by microbubbles. Journal of Controlled Release 2010; 142:31-39.v