Dr. Gumucio completed her B.A. (1971), M.P.H. (1975), Ph.D. (1986) and postdoctoral studies with Francis S. Collins (1986-1991) at the University of Michigan. She joined the faculty of the Department of the Anatomy and Cell Biology at Michigan in 1991. Dr. Gumucio founded the Center for Organogenesis at Michigan in 1995 and served as its Co-Director and Director for the 20 years. The Center serves to bring together clinical, basic and applied scientists in the study of organogenesis and its relationship to human disease.
Dr. Gumucio has maintained a diverse and well-funded research effort in the areas of organogenesis and morphogenesis. Her laboratory studies the molecular control of gut development, factors responsible for intestinal lengthening and the role of Hedgehog signaling in villus formation. Recently, she has been study the formation and maturation of the apical surface of the intestine, studies that have led her to investigate several in vitromodels of lumen formation and apical polarization. The Gumucio lab made the surprising observation that isolated pluripotent cells form lumens upon cell division. In studying this phenomenon, they discovered that the lumen begins to form even in single cells, beginning with the generation of a proto-lumen-like structure called an apicosome. They further found that this interesting structure is the precursor to the human amniotic cavity and its discovery is allowing the lab to study events of peri-implantation human development (epiblast polarization, amniogenesis) that have never before been captured in vitroand cannot (for ethical reasons) be studied in vivo. Throughout her career, Gumucio has been fascinated by the beauty of cells and tissues. This led her to establish the BioArtography Project in 2005. Through funds earned from the sale of biological images, BioArtography has given nearly 100 travel awards to trainees in the basic, clinical and applied sciences to attend national and international meetings. Additionally, the project has served an important education/outreach role, teaching the public why it is so important to study brain development in the fruit fly, vesicular trafficking in yeast or cell division in bacteria.
Walton, K.D., Kolterud, Å, Czerwinski M.J., Prakash, A., Bell, M., Kushwaha, J., Grosse, A.S., Schnell, S., and Gumucio, D.L. Hedgehog-responsive mesenchymal cell clusters direct patterning and emergence of intestinal villi. PNAS, 109:15817-22, 2012. PMCID:PMC3465418. Cited by Faculty of 1000
Whiteman, E.L., Fan, S., Harder, J.L., Walton, K.D., Liu, C-J., Soofi, A., Fogg, V.C., Hershenson, M.B., Dressler, G.R., Deutsch, G.H., Gumucio, D.L. and Margolis, B.: Crumbs3 is Essential for Proper Epithelial Development and Viability. Molecular and Cellular Biology, 34:43-56, 2013. PMID:24164893; PMCID:PMC3911272
Udager, A., Prakash, A., Saenz, D., Lim, K.C., Jay, P., Engel, J.D. and Gumucio, D.L: Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3. Gastroenterology, 146:157-165, 2013. PMCID:PMC3889663
Prakash, A., Udager, A.M., Saenz, D. and Gumucio, D.L.: Roles for Nkx2-5 and Gata3 in the ontogeny of the murine smooth muscle pyloric ligaments. Am. J. Phys., 307:G430-6, 2014. PMID:24970776; PMCID:PMC4137113
Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Uygur A, Schwartz M, Gross S, Setlik W, Chen XM, Martinez AN, Nizami S, Caldwell J-M, Renz BW, Asfaha S, Westphalen CB, Hayakawa Y, Jin G, Nagar K, Wang H, Kolhe A, Carpenter J, Glaire M, Nair A, Muley A, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere J-P, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Grikscheit T, Lee FY, Karsenty G, Mukherjee S and Wang TC. Gremlin 1 identifies a skeletal stem cell with bone, cartilage and reticular stromal potential. Cell, 160:269-84, 2015. PMID:25594183; PMCID in progress. Cited by Faculty of 1000.
Taniguchi K., Townshend R.F., Freddo A.M., Prakash A., Gayen S., Harris C.E., Tsai Y-H., DeLong C.J., Chue D.J., Lopez S.A., Spence J.R., O’Shea K.S., Margolis B., Kalantry S. and Gumucio D.L. Pluripotent stem cells: an improved model of lumen formation. In revision, Stem Cell Reports, In press, 2015