PhD from Rensselaer Polytechnic Institute in the area of chromatographic separations
Harvard Medical School, postdoc in metabolic and tissue engineering
Rice University, Assistant Professor, focus on the systems biology of human disease
Directs the Nagrath lab, which focuses on both experimental and theoretical aspects of Cellular and Molecular Tissue Engineering, Metabolic Engineering, and Biomedicine with emphasis on clinical applications. Our research interests lie in the systems biology of metabolic diseases, specifically cancer. http://nagrath.bme.umich.edu/
Deepak Nagrath's expertise is in the development of metabolic and nutritional systems biology approaches for cancer and other diseases.
His work combines the experimental technique of metabolic isotope tracing with a computational framework known as 13C-based metabolic flux analysis. Using a systems biology approach, his lab aims to identify the critical metabolic regulators of cancer metastasis and the role the tumor microenvironment plays in modulating cancer cell metabolism. He hopes his studies will provide avenues for targeting cancer cells in a stage-specific manner and for treating tumors’ heterogeneous cell populations with drug cocktails targeting mutually compensatory metabolic pathways.
Nagrath’s lab has published several recent findings in these areas. In Cell Metabolism, they showed that targeting stromal glutamine synthetase disrupts tumor microenvironment-mediated cancer cell growth and used a synthetic lethal approach to target tumor stroma and cancer cells simultaneously. In eLife, they uncovered the metabolic role of exosomes secreted by tumor microenvironment in cancer metabolism. In Nature Communications, they applied metabolic and bioinformatic tools to analyze genes in the ubiquitin-proteasome proteolytic pathways to determine their molecular interactions with cell metabolism. And in Molecular Systems Biology, they showed that invasive ovarian cancer cells are glutamine-dependent and that glutamine selectively supports high-invasive versus low-invasive ovarian cancer cell growth through glutaminolysis and STAT3 signaling.
Nagrath looks forward to strong collaborations with cancer researchers and hopes to support colleagues interested in incorporating metabolic aspects into their research. He is also eager to collaborate with immunologists to decipher metabolic targets for immunotherapy.
Prasenjit Dey*, Joelle Baddour*, Florian Muller, Chia Chin Wu, Huamin Wang, Wen-Ting Liao, Zangdao Lan, Alina Chen, Tony Gutschner, Yaan Kang, Jason Fleming, Nikunj Satani, Di Zhao, Abhinav Achreja, Lifeng Yang, Jiyoon Lee, Edward Chang, Giannicola Genovese, Andrea Viale, Haoqiang Ying, Giulio Draetta, Anirban Maitra, Y. Alan Wang, Deepak Nagrath# & Ronald A. DePinho#, Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer, Nature, 2016. * Equal Contribution, # co-Corresponding Authors. Abhinav Achreja*, Hongyun Zhao*, Lifeng Yang, Tae Hyun Yun, Juan Marini, Deepak Nagrath, Exo-MFA – A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism, Metabolic Engineering, 2016 (in press). * Equal Contribution Cecil Han*, Lifeng Yang*, Y. Liu, Joelle Baddour, Abhinav Achreja, Deepak Nagrath#, X. Lu#, USP13 Regulates Glutamine Metabolism In Cancer Cell, Nature Communications, 7, 13525, 2016. * Equal Contribution, # co-Corresponding Authors. Yang L, Achreja A, Yeung TL, Mangala LS, Jiang D, Han C, Baddour J, Marini JC, Ni J, Nakahara R, Wahlig S, Chiba L, Kim SH, Morse J, Pradeep S, Nagaraja AS, Haemmerle M, Kyunghee N, Derichsweiler M, Plackemeier T, Mercado-Uribe I, Lopez-Berestein G, Moss T, Ram PT, Liu J, Lu X, Mok SC, Sood AK, Nagrath D. (2016). Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth. Cell Metabolism. 2016 Nov 8;24(5):685-700. doi: 10.1016/j.cmet.2016.10.011. Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J., Tudawe, T., Seviour, E.G., San Lucas, F.A., Alvarez, H., Gupta, S., Maiti, S.N., Cooper, L., Peehl, D., Ram, P.T., Maitra, A., Nagrath, D. (2016). Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife 5. eLife