Daniel R. Goldstein obtained his medical degree from St. George’s, University of London, UK. He undertook a medical residency at Johns Hopkins Bayview Medical Center in Baltimore, MD, USA and his cardiovascular disease, heart failure and transplantation training at the University of Alabama, Birmingham (UAB).
For more than a decade, Dr. Goldstein’s lab defined how activation of specific inflammatory pathways results in organ rejection after transplantation. His laboratory was the first to define the role of the Toll-like Receptors (TLRs) in organ transplantation by showing that TLRs were required for murine skin graft rejection (JCI 2003). They then defined the functions of TLRs and downstream mediators (e.g., MyD88) in acute cardiac allograft rejection (AJT, 2004) and in transplantation tolerance (JI, 2006, JASN, 2009). They identified an extracellular matrix component, hyaluronan, which activates TLRs to enhance alloimmunity and demonstrated that elevated hyaluronan levels correlate with human chronic lung rejection (AJT, 2006). Recently, via a proteomic screen, they identified haptoglobin as a unique activator of MyD88 that enhances skin graft rejection (JCI, 2012) and impairs indefinite survival of cardiac allografts (Circ Res, 2015). Their work has been clinically translated and has led to the development of TLR inhibition strategies in solid organ transplantation.
Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP: Future Research Directions in Pneumonia: NHLBI Working Group Report. American Journal of Respiratory and Critical Care Medicine. 2018 Mar 16; PMID: 29546996.
Goldstein DR, Jalife J. Synergistic Research Between the Center of Arrhythmia Research and the Michigan Biology of Cardiovascular Aging at the University of Michigan. Circulation Research. 2017 Nov 10; PMID: 29122944.
Anumonwo JM, Jalife J, Goldstein DR. Triple threat: adiposity, aging, atrial fibrillation. Aging. 2017 Nov 1; PMID: 29112501.
Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR. Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. Journal of Immunology. 2017 June 23; PMID: 28646038.
Colvin MM, Smith CA, Tullius SG, Goldstein DR. Aging and the immune response to organ transplantation. Journal of Clinical Investigation. 2017 May 15; PMID: 28504651.